Table 2 Hazard ratios of single CID events and composite CID events for CID + patients versus CID- patients

Model 1

Single CID components

FEV₁ decrease (≥ 100 mL)

0.78 (0.47−1.26)

0.32

0.64 (0.25−1.44)

0.29

1.28 (0.84−1.91)

0.25

1.23 (0.63−2.29)

0.53

FEV₁ decrease (≥ 200 mL)

0.59 (0.23−1.26)

0.19

0.98 (0.23−2.81)

0.97

1.39 (0.74−2.42)

0.29

1.77 (0.72−3.80)

0.20

SGRQ increase (≥ 4 units)

1.01 (0.61−1.62)

0.97

1.78 (0.82−3.74)

0.14

1.33 (0.88−1.99)

0.17

1.67 (0.88−3.08)

0.11

SGRQ increase (≥ 8 units)

1.28 (0.70−2.19)

0.41

2.88 (1.28−6.14)

0.01

1.39 (0.86−2.18)

0.17

2.28 (1.11−4.43)

0.03

Exacerbation

2.87 (1.64−4.83)

0.0004

1.09 (0.32−2.88)

0.87

1.17 (0.65−1.97)

0.59

1.00 (0.38−2.21)

1.00

Composite CID

CID using D1

1.44 (0.90−2.34)

0.13

1.21 (0.57−2.73)

0.63

1.52 (1.006−2.34)

0.047

1.96 (1.02−4.02)

0.04

CID using D2

1.78 (1.12−2.81)

0.01

2.09 (0.98−4.53)

0.06

1.48 (0.997−2.20)

0.052

1.87 (0.9997−3.50)

0.0501

Model 2

Single CID components

FEV₁ decrease (≥ 100 mL)

0.79 (0.48–1.26)

0.32

0.62 (0.24–1.40)

0.26

1.27 (0.84–1.90)

0.26

1.25 (0.64–2.33)

0.50

FEV₁ decrease (≥ 200 mL)

0.60 (0.23–1.28)

0.21

1.03 (0.24–2.96)

0.96

1.40 (0.74–2.44)

0.28

1.79 (0.72–3.83)

0.19

SGRQ increase (≥ 4 units)

0.93 (0.56–1.50)

0.77

1.65 (0.76–3.49)

0.20

1.28 (0.84–1.92)

0.24

1.46 (0.76–2.74)

0.25

SGRQ increase (≥ 8 units)

1.10 (0.60–1.89)

0.75

2.59 (1.15–5.53)

0.02

1.33 (0.82–2.10)

0.24

1.99 (0.95–3.91)

0.07

Exacerbation

2.25 (1.28–3.82)

0.006

0.81 (0.23–2.18)

0.70

1.12 (0.62–1.89)

0.70

0.85 (0.32–1.93)

0.72

Composite CID

CID using D1

1.35 (0.85–2.20)

0.21

1.07 (0.50–2.44)

0.86

1.48 (0.98–2.28)

0.07

1.80 (0.93–3.71)

0.08

CID using D2

1.54 (0.97–2.44)

0.07

1.79 (0.84–3.89)

0.13

1.44 (0.96–2.14)

0.08

1.66 (0.88–3.14)

0.12