Table 2 The baseline data and prognosis of patients who received reintubation within 48 h of and 48 h after extubation in the two groups
Treatment group n = 358 | Control group n = 443 | |||||||
|---|---|---|---|---|---|---|---|---|
All reintubations n = 79 | Within 48 h n = 40 | 48 h after n = 39 | P value | All reintubations n = 81 | Within 48 h n = 55 | 48 h after n = 26 | P value | |
Age, median[Q1, Q3] | 67.68[57.02, 78.00] | 64.47[49.57, 77.97] | 68.83[62.52, 77.59] | 0.202 | 71.82[62.27, 78.93] | 71.52[60.69, 78.69] | 73.40[64.81, 78.74] | 0.485 |
Male, n (%) | 59(74.68) | 31(77.50) | 28(71.79) | 0.746 | 48(59.26) | 29(52.73) | 19(73.08) | 0.134 |
BMI, mean (SD) | 29.65(5.87) | 28.99(5.72) | 30.38(6.02) | 0.314 | 32.60(9.00) | 31.12(8.34) | 35.67(9.71) | 0.051 |
Baseline disease | ||||||||
Hypertension, n (%) | 41(51.90) | 18(45.00) | 23(58.97) | 0.309 | 54(66.67) | 33(60.00) | 21(80.77) | 0.110 |
Diabetes mellitus, n (%) | 12(15.19) | 7(17.50) | 5(12.82) | 0.790 | 13(16.05) | 7(12.73) | 6(23.08) | 0.331 |
COPD, n (%) | 5(6.33) | 3(7.50) | 2(5.13) | 1.000 | 9(11.11) | 5(9.09) | 4(15.38) | 0.458 |
Congestive heart failure, n (%) | 23(29.11) | 10(25.00) | 13(33.33) | 0.570 | 29(35.80) | 17(30.91) | 12(46.15) | 0.277 |
Myocardial infarction, n (%) | 6(7.59) | 4(10.00) | 2(5.13) | 0.675 | 14(17.28) | 9(16.36) | 5(19.23) | 0.760 |
Chronic kidney disease, n (%) | 17(21.52) | 5(12.50) | 12(30.77) | 0.089 | 21(25.93) | 10(18.18) | 11(42.31) | 0.041 |
Leukaemia, n (%) | 1(1.27) | 0 | 1(2.56) | 0.494 | 2(2.47) | 1(1.82) | 1(3.85) | 0.542 |
Strokes, n (%) | 8(10.13) | 1(2.50) | 7(17.95) | 0.029 | 6(7.41) | 4(7.27) | 2(7.69) | 1.000 |
Cancer, n (%) | 10(12.66) | 6(15.00) | 4(10.26) | 0.737 | 16(19.75) | 9(16.36) | 7(26.92) | 0.415 |
Liver disease, n (%) | 12(15.19) | 7(17.50) | 5(12.82) | 0.790 | 14(17.28) | 8(14.55) | 6(23.08) | 0.360 |
SAPS-II at admission, mean (SD) | 44.32(13.08) | 43.30(10.86) | 45.36(15.09) | 0.490 | 47.20(13.72) | 46.73(13.48) | 48.19(14.45) | 0.665 |
Duration before extubation, median [Q1,Q3], hours | 61.50[20.33, 125.27] | 53.92[15.14, 110.82] | 67.35[22.86, 138.07] | 0.364 | 38.90[20.25, 131.67] | 40.83[23.53, 128.29] | 28.46[17.63, 127.40] | 0.413 |
Physiological variables before extubation 4 h | ||||||||
Heart rate, mean (SD) | 87.28(15.55) | 89.67(16.07) | 84.84(14.80) | 0.168 | 86.00(16.39) | 87.03(14.03) | 83.81(20.67) | 0.476 |
Respiratory rate, mean (SD) | 19.10(4.67) | 19.41(4.09) | 18.78(5.23) | 0.556 | 19.73(4.17) | 19.70(4.42) | 19.79(3.64) | 0.920 |
Tidal volume, mean (SD) | 534.45(132.46) | 527.92(146.70) | 539.43(122.28) | 0.734 | 454.31(111.36) | 448.81(112.36) | 466.35(110.87) | 0.553 |
MBP, mean (SD) | 79.62(12.93) | 81.10(13.91) | 78.10(11.82) | 0.304 | 77.45(10.11) | 77.61(10.55) | 77.13(9.31) | 0.836 |
pH, mean (SD) | 7.41(0.07) | 7.39(0.07) | 7.42(0.06) | 0.068 | 7.39(0.05) | 7.39(0.06) | 7.38(0.05) | 0.831 |
PaO2, median [Q1, Q3] | 91.00[82.00, 107.00] | 89.25[83.50, 104.62] | 95.50[81.17, 110.50] | 0.444 | 96.00[87.00, 108.00] | 95.00[85.75, 106.25] | 98.25[89.54, 115.00] | 0.347 |
PaCO2, mean (SD) | 39.76(6.76) | 39.52(6.60) | 40.01(6.99) | 0.751 | 44.79(10.47) | 45.58(11.74) | 43.10(7.01) | 0.240 |
SpO2, median [Q1, Q3] | 97.00[95.54, 98.69] | 96.50[95.00, 98.29] | 97.25[96.38, 98.88] | 0.088 | 97.25[95.50, 98.60] | 97.80[95.75, 98.78] | 96.50[95.56, 97.93] | 0.172 |
PaO2/FiO2, median [Q1,Q3] | 209.00[175.50, 248.62] | 208.00[170.00, 229.86] | 217.50[189.75, 254.30] | 0.233 | 220.00[187.50, 252.52] | 213.00[186.50, 254.32] | 221.88[192.12, 249.65] | 0.712 |
Mortality 28 days, n (%) | 13(16.46) | 4(10.00) | 9(23.08) | 0.206 | 12(14.81) | 7(12.73) | 5(19.23) | 0.509 |