Effects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database

Table 4 Predicting power of HFNC failure by HR/PaO₂, HR/SpO₂, RSBI and the ROX index at 4 h before and after extubation

	AUC (95% CI)	P	Cutoff value	Youden Index	Sensitivity	Specificity	PPV	NPV
4 h before extubation
HR/PaO₂	0.640 [0.584, 0.694]	P < 0.01	0.829	0.263	0.733	0.530	0.159	0.943
HR/SpO₂	0.618 [0.551, 0.683]	P < 0.01	0.830	0.215	0.733	0.481	0.146	0.937
RSBI	0.541 [0.467, 0.607]	P < 0.01	48.4	0.120	0.413	0.707	0.146	0.909
ROX index	0.551 [0.488, 0.610]	P < 0.01	0.107	0.168	0.640	0.528	0.141	0.924
4 h after extubation
HR/SpO₂	0.657 [0.571, 0.724]	P < 0.01	1.203	0.330	0.400	0.930	0.462	0.911
ROX index	0.583 [0.519, 0.629]	P < 0.01	6.376	0.020	0.800	0.220	0.133	0.880

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