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Table 4 Predicting power of HFNC failure by HR/PaO2, HR/SpO2, RSBI and the ROX index at 4 h before and after extubation

From: Effects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database

  AUC (95% CI) P Cutoff value Youden Index Sensitivity Specificity PPV NPV
4 h before extubation
 HR/PaO2 0.640 [0.584, 0.694] P < 0.01 0.829 0.263 0.733 0.530 0.159 0.943
 HR/SpO2 0.618 [0.551, 0.683] P < 0.01 0.830 0.215 0.733 0.481 0.146 0.937
 RSBI 0.541 [0.467, 0.607] P < 0.01 48.4 0.120 0.413 0.707 0.146 0.909
 ROX index 0.551 [0.488, 0.610] P < 0.01 0.107 0.168 0.640 0.528 0.141 0.924
4 h after extubation
 HR/SpO2 0.657 [0.571, 0.724] P < 0.01 1.203 0.330 0.400 0.930 0.462 0.911
 ROX index 0.583 [0.519, 0.629] P < 0.01 6.376 0.020 0.800 0.220 0.133 0.880