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Table 1 Initial variables of the whole cohort (fever > 72 h)

From: Prediction model for prolonged fever in patients with Mycoplasma pneumoniae pneumonia: a retrospective study of 716 pediatric patients

  Training cohort (n = 501) Test cohort (n = 215)
Fever ≥  72 h Fever < 72 h p-value Fever ≥ 72 h Fever < 72 h p-value
Number of patients (n, %) 163 (32.5) 338 (67.5)   79 (36.7) 136 (63.3)  
Age, mean (years) 5.9 ± 2.8 5.5 ± 3.2 0.140 5.8 ± 2.5 5.3 ± 3.1 0.273
Sex ratio (female: male) 1.3 1.0 0.124 1.7 0.7 0.002
Duration of fever (days)
 At admission 4.8 ± 1.8 5.1 ± 2.2 0.057 4.9 ± 1.7 4.9 ± 2.0 0.960
 After admission 4.8 ± 3.4 1.3 ± 1.0 < 0.001 4.9 ± 3.3 1.3 ± 0.9 < 0.001
 Total 9.4 ± 3.3 6.5 ± 2.3 < 0.001 9.5 ± 3.0 6.3 ± 2.1 < 0.001
 Total hospital days (days) 9.2 ± 3.5 5.4 ± 1.6 < 0.001 9.4 ± 3.6 5.5 ± 1.8 < 0.001
Initial inflammatory markers
 WBC × 103/µL 7.6 ± 3.5 9.6 ± 7.0 0.001 7.5 ± 3.2 9.7 ± 5.5 < 0.001
  Neutrophils (%) 67.0 ± 10.7 63.0 ± 14.2 0.001 68.0 ± 10.8 61.9 ± 14.2 0.001
  Absolute neutrophil count × 103/µL 5.2 ± 2.9 6.2 ± 5.3 0.003 5.1 ± 2.4 6.2 ± 4.8 0.031
  Lymphocytes (%) 23.2 ± 8.4 26.6 ± 12.4 < 0.001 22.9 ± 8.4 27.7 ± 12.8 0.001
  Absolute lymphocyte count × 103/µL 1.1 ± 0.5 1.4 ± 1.1 < 0.001 1.1 ± 0.6 1.4 ± 0.7 0.001
 Platelet × 103/µL 242.0 ± 75.9 304.9 ± 100.4 < 0.001 234.9 ± 71.1 308.6 ± 101.1 < 0.001
 ESR (mm/hr) 38.3 ± 18.4 35.9 ± 18.5 0.178 37.4 ± 17.3 32.5 ± 17.4 < 0.001
 CRP (mg/L) 49.2 ± 45.6 24.7 ± 30.6 < 0.001 57.7 ± 53.9 24.1 ± 27.7 < 0.001
 Procalcitonin (ng/mL) 0.6 ± 1.2 0.7 ± 2.4 0.700 0.5 ± 0.7 0.3 ± 0.6 0.169
Other laboratory data
 LDH (IU/L) 359.8 ± 107.4 326.2 ± 73.1 < 0.001 372.6 ± 132.8 332.7 ± 90.7 0.019
 AST (IU/L) 40.3 ± 17.9 36.2 ± 29.3 0.104 39.4 ± 14.9 41.5 ± 48.5 0.701
 ALT (IU/L) 19.6 ± 13.3 22.6 ± 64.9 0.556 15.9 ± 7.3 29.2 ± 77.9 0.051
Concurrent respiratory virus (n, %) 36/140 (25.7) 95/285 (33.3) 0.110 18/64 (28.1) 39/117 (33.3) 0.471
Oxygen requirement (n, %) 5 (3.1) 8 (2.4) 0.765 3 (3.8) 2 (1.5) 0.359
Radiologic grouping (n, %)
 Group 1 13 (8.0) 108 (32.0) < 0.001 7 (8.9) 44 (32.4) < 0.001
 Group 2 54 (33.1) 161 (47.6)   22 (27.8) 67 (49.3)  
 Group 3 85 (52.1) 68 (20.1)   41 (51.9) 24 (17.6)  
 Group 4 11 (6.7) 1 (0.3)   9 (11.4) 1 (0.7)  
Pleural effusion (n, %) 34 (20.9) 20 (5.9) < 0.001 18 (22.8) 6 (4.4) < 0.001
Radiologic aggravation on the 3rd or 4th hospital day (n, %) 121 (74.2) 29 (8.6) < 0.001 61 (77.2) 15 (11.0) < 0.001
  1. ESR erythrocyte sedimentation rate, CRP C-reactive protein, LDH lactate dehydrogenase, AST aspartate aminotransferase, ALT alanine aminotransferase, WBC white blood cell
  2. Continuous variables are presented as mean ± standard deviation
  3. Categorical variables are presented as frequencies (%)