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Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network

Fig. 6

CDKN2B-AS1 promoted the LPS-induced cell injury via the miR-140-5p/TGFBR2/Smad3 axis. a, b The qRT-PCR and western blot were respectively performed to detect TGFBR2 mRNA expression (a) and TGFBR2/Smad3 protein levels (b) after si-NC, si-CDKN2B-AS1#1, si-CDKN2B-AS1#1 + anti-NC or si-CDKN2B-AS1#1 + anti-miR-140-5p transfection. GAPDH was used as an internal control, and the protein expression in other three groups was relative to si-NC group (set as 1). c The graphical summary of the CDKN2B-AS1/miR-140-5p/TGFBR2/Smad3 axis in the regulation of LPS-induced cell damages. The number of replicates for each experiment was 3 (n = 3). One-way analysis of variance (ANOVA) followed by Tukey’s test was used for statistical analysis. **P < 0.01, ***P < 0.001

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BMC Pulmonary Medicine

ISSN: 1471-2466

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