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Table 1 Association between self-reported demographic factors and severe and non-severe asthma groups

From: Risk factors for severe adult-onset asthma: a multi-factor approach

  Non-severe asthma
N = 1250
Severe asthma
N = 100
P
Personal characteristics
Female sex, n (%) 793 (63.4) 45 (45.0)  < .001
Age, years, mean(SD) 54.0 (12.2) 58.7 (11.6) .001
BMI1, mean (SD) 26.9 (4.7) 27.1 (5.5) .94
Socio-economic characteristics
Baccalaureate/secondary school, n (%) 754 (61.8) 71 (76.3) .005
Professional training, n (%) 296 (26.0) 35 (40.7) .004
Lifestyle factors
Ever smokers, n (%) 720 (57.6) 74 (74.0) .001
Early-life factors
1st child, n (%) 363 (29.0) 22 (22.0) .14
 ≥ 2 siblings, n (%) 927 (75.9) 84 (89.4) .003
Growing up in the countryside/on a farm, n (%) 937 (75.9) 77 (80.2) .39
Severe childhood infections2, n (%) 217 (18.0) 11 (11.7) .13
Parental smoking, n (%) 648 (51.8) 53 (53.0) .84
Parental asthma and/or allergy, n (%) 437 (36.1) 29 (29.9) .23
Asthma characteristics
NERD, n (%) 124 (9.9) 19 (19.0) .007
Multimorbidity
CRSwNP, n (%) 145 (11.6) 7 (7.0) .19
 ≥ 1 other disease3, n (%) 843 (67.4) 86 (86.0)  < .001
 ≥ 1 other allergic disease (AR/AC/AD), n (%) 844 (67.5) 63 (63.0) .38
  1. Bold values denote statistical significance at the p < 0.05 level
  2. NERD = patient-reported NSAID-exacerbated respiratory disease; CRSwNP = chronic rhinosinusitis with nasal polyps; AR = allergic rhinitis; AC = allergic rhinoconjunctivitis, AD = atopic dermatitis. P values by Chi square test (dichotomous) or t-test (continuous variables). P values less than 0.05 were considered significant. 1BMI data were missing from 6 (6.0%) severe asthmatic patients and 29 (2.3%) non-severe asthmatic patients. 2pneumonia before or during school age and/or hospitalization due to infection at ≤ 3 years of age. 3Hypertension (n = 298), coronary artery disease (n = 120), rheumatoid arthritis (n = 60), psychiatric disorder (n = 86), diabetes (n = 54), glaucoma (n = 49), back disease (n = 367), arthritis (n = 244), empyema (n = 106), other chronic disease(s) except chronic bronchitis/bronchiectasis (n = 449). Education level = baccalaureate/secondary versus primary school; professional training = completed professional college/university/courses/trade school versus no professional training. Severe asthma (Sev-Q) was defined as self-reported severe asthma and asthma symptoms causing much harm and regular impairment and ≥ 1 oral corticosteroid course/year or regular oral corticosteroids and/or waking up in the night due to asthma symptoms/wheezing ≥ a few times/month. Missing values were included and regarded as “no”