LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease

Table 6 Association of polymorphisms with dyspnea and wheezing in COPD patients

SNP ID	Model	Genotype	COPD with dyspnea				COPD with wheezing
SNP ID	Model	Genotype	Yes	No	OR (95%CI)	p	Yes	No	OR (95%CI)	p
LINC01414 rs298207	Allele	G	180	242	1		239	179	1
	Allele	A	48	82	0.79 (0.52–1.18)	0.246	65	59	0.83 (0.55–1.23)	0.349
	Genotype	GG	76	90	1		94	71	1
		GA	28	62	0.50 (0.29–0.88)	0.016*	51	37	1.03 (0.60–1.74)	0.925
		AA	10	10	0.91 (0.34–2.45)	0.852	7	11	0.40 (0.14–1.13)	0.083
	Dominant	GG	76	90	1		94	71	1
	Dominant	GA-AA	38	72	0.56 (0.33–0.94)	0.029*	58	48	0.88 (0.54–1.45)	0.615
	Recessive	GG-GA	104	152	1		145	108	1
	Recessive	AA	10	10	1.16 (0.44–3.05)	0.768	7	11	0.40 (0.14–1.10)	0.075
	Log-additive	–			0.72 (0.47–1.08)	0.110			0.80 (0.54–1.18)	0.260
LINC00824 rs7815944	Allele	A	170	242	1		237	169	1
	Allele	G	60	90	0.95 (0.65–1.39)	0.788	69	77	0.64 (0.44–0.93)	0.021*
	Genotype	AA	62	87	1		89	58	1
		AG	46	68	0.95 (0.57–1.59)	0.843	59	53	0.72 (0.44–1.20)	0.209
		GG	7	11	0.61 (0.21–1.75)	0.358	5	12	0.22 (0.07–0.67)	0.008*
	Dominant	AA	62	87	1		89	58	1
	Dominant	AG-GG	53	79	0.89 (0.55–1.47)	0.660	64	65	0.63 (0.39–1.02)	0.059
	Recessive	AA-AG	108	155	1		148	111	1
	Recessive	GG	7	11	0.63 (0.22–1.74)	0.369	5	12	0.25 (0.08–0.76)	0.014*
	Log-additive	–			0.86 (0.58–1.29)	0.472			0.59 (0.40–0.89)	0.011*

p values were calculated by logistic regression analysis adjusted by age and gender
Bold indicate that p < 0.05 means the data is statistically significant
COPD chronic obstructive pulmonary disease, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval

ISSN: 1471-2466