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Table 5 Mortality at 30 days and end of follow-up following respiratory hospitalizations, ICU hospitalizations, and ICU hospializations with and without mechanical ventilation

From: Outcomes for hospitalized patients with idiopathic pulmonary fibrosis treated with antifibrotic medications

  Untreated Treated Statistical Analysis
All respiratory hospitalizations N = 402 N = 402  
30 day mortality, total (%) 40 (10.0) 41 (10.2) HR 0.96 (CI 0.70–1.33), p = 0.812
End of follow-up mortality, total (%) 192 (47.8) 81 (20.1) HR 0.59 (CI 0.45–0.77), p < 0.001
Months of follow-up mean(SD) 10.6 (12.1) Median: 5.3 6.3 (8.9) Median: 2.2  
ICU hospitalizations N = 274 N = 274  
30 day mortality, total (%) 45 (16.4) 49 (17.9) HR 1.05 (CI 0.71–1.58) p = 0.782
End of follow-up mortality, total (%) 140 (51.1) 102 (37.2) HR 0.79 (CI 0.61–1.02) p = 0.075
Months of follow-up mean (SD) 8.7 (11.5) Median: 3.1 7.2 (10.4) Median: 2.4  
ICU Hospitalizations w/all mechanical ventilation N = 94 N = 94  
30 day mortality, total (%) 29 (30.9) 27 (28.7) HR 0.91 (CI 0.52–1.59) p = 0.734
End of follow-up mortality, total (%) 66 (70.2) 50 (53.2) HR 0.64 (CI 0.43–0.94) p = 0.021
Months of Follow-up mean (SD) 6.3 (10.7) Median: 1.18 4.1 (6.2) Median: 1.55  
ICU hospitalizations w/non-invasive mechanical ventilation N = 60 N = 60  
30 day mortality, total (%) 13 (21.7) 13 (21.7) HR 0.94 (CI 0.34–2.57) p = 0.907
End of follow-up mortality, tota l(%) 39 (65.0) 26 (43.3) HR 0.80 (CI 0.43–1.47) p = 0.472
Months of Follow-up mean (SD) 7.13 (11.02) Median: 2.37 4.73 (6.71) Median: 1.87  
ICU hospitalizations w/invasive mechanical ventilation N = 34 N = 34  
30 day mortality, total (%) 10 (29.4) 14 (41.2) HR 1.78 (CI 0.55–5.79) p = 0.339
End of follow-up mortality, total (%) 26 (76.5) 24 (70.6) HR 1.47 (CI 0.66–3.27) p = 0.345
Months of Follow-up mean (SD) 8.25 (13.95) Median: 1.18 3.03 (5.11) Median: 1.05  
ICU hospitalizations w/out mechanical ventilation N = 180 N = 180  
30 day mortality, total (%) 21 (11.7) 22 (12.2) HR 1.00 (CI 0.56–1.83) p = 0.980
End of follow-up mortality, total (%) 79 (43.9) 52 (28.9) HR 0.71 (CI 0.50–1.00) p = 0.055
Months of Follow-up mean (SD) 10.0 (11.5) Median: 5.9 8.8 (11.7) Median: 3.0