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Table 2 Trial process chart

From: Rationale and design of REGULATE: an observational study protocol for relationship between plasma metabolome and the efficacy of systemic glucocorticoid in acute exacerbation of chronic obstructive pulmonary disease

Period Run-in period Treatment period Follow-up period
Week − 1 0 to discharge 12, 24, 36, 48 weeks after discharge
Informed consent   
Inclusion/exclusion criteria   
Examination
Medical examination  
Blood test  
Liver function test   
Electrocardiogram   
Pulmonary function tests  
mMRC and CAT scoring  
Evaluation of glucocorticoids adverse effects   
Treatment and BGAV scoring
Bronchodilators  
Glucocorticoids  
Antibiotics   
Ventilation   
Blood specimens for metabolomics analysis