Table 2 Trial process chart
Period | Run-in period | Treatment period | Follow-up period |
|---|---|---|---|
Week | − 1 | 0 to discharge | 12, 24, 36, 48 weeks after discharge |
Informed consent | √ | ||
Inclusion/exclusion criteria | √ | ||
Examination | |||
Medical examination | √ | √ | |
Blood test | √ | √ | |
Liver function test | √ | ||
Electrocardiogram | √ | ||
Pulmonary function tests | √ | √ | |
mMRC and CAT scoring | √ | √ | |
Evaluation of glucocorticoids adverse effects | √ | ||
Treatment and BGAV scoring | |||
Bronchodilators | √ | √ | |
Glucocorticoids | √ | √ | |
Antibiotics | √ | ||
Ventilation | √ | ||
Blood specimens for metabolomics analysis | √ | √ | √ |