| |
Malignant (n = 156)
|
Benign (n = 94)
|
P value
|
|---|
|
Gender (male/female)
|
85/71
|
56/38
|
0.432
|
|
Age (y)
|
65.4
|
53.5
|
< 0.001
|
|
Smoking history
|
72
|
38
|
0.377
|
|
Malignant history
|
5
|
1
|
0.519
|
|
CT features
|
|
Diameter (mm)
|
16.8
|
13.6
|
< 0.001
|
|
Lobulation
|
114
|
49
|
0.001
|
|
Spiculation
|
120
|
47
|
< 0.001
|
|
Pleural retraction sign
|
75
|
17
|
< 0.001
|
|
CT bronchus sign
|
104
|
34
|
< 0.001
|
|
Calcification
|
3
|
9
|
0.006
|
|
Mediastinal/hilar lymph nodule ≥ 10 mm
|
38
|
14
|
0.074
|
|
Lobes
| | |
0.951
|
|
Upper
|
67
|
40
| |
|
Non-upper
|
89
|
54
| |
|
Sides
| | |
0.897
|
|
Left
|
76
|
45
| |
|
Right
|
80
|
49
| |
|
Tumor markers
|
|
CEA (ug/L)
|
3.9
|
2.3
|
< 0.001
|
|
Cyfra21-1 (ng/ml)
|
13.5
|
12.7
|
0.099
|
|
SCC (ug/L)
|
1.4
|
1.1
|
0.211
|
|
NSE (ng/ml)
|
2.5
|
2.4
|
0.423
|
- CEA: Carcinoembryonic antigen; CT: Computed tomography; NSE: Neuron-specific enolase; SCC: Squamous cell carcinoma antigen
