Fig. 1

Volcano plot for the differentially expressed genes (a) and DNA methylation data (b). The horizontal dotted line represents an FDR = 0.05 threshold line;the red vertical dotted line represents the | logFC | > 0.5 threshold line; the red and blue dots represent significantly up-regulated and down-regulated DEGs and DMGs, respectively; and the black dots represent the non-differential expression genes. Bidirectional hierarchical clustering heatmaps for differentially expressed genes (c) and differentially expressed methylation regions (d). Black represents asthmatic samples and white represents healthy controls. FDR, false discovery rate; FC, fold change; DEGs, differentially expressed genes; DMGs, differentially methylated genes