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Table 4 Review of our and previous retrospective studies of prognostic factors in DAH

From: High neutrophils and low lymphocytes percentages in bronchoalveolar lavage fluid are prognostic factors of higher in-hospital mortality in diffuse alveolar hemorrhage

Authors (year)

Prost [2]

Rabe [3]

Otoshi [9]

Mirouse [5]

Ours

Participants of studies

Patients number, n

97

37

76

104

68

Patients with AT, n

Not described

Not described

39

Not described

48

IMV, n (%)

17 (18%)

32 (86%)

Not described

52 (50%)

38 (56%)

Mortality rate, n (%)

24 (25%)

19 (51%)

29 (38%)

16 (15%)

18 (27%)

Factors associated with mortality

Univariate analyses

Demographics

Age

Age

Comorbidities

CVD

Cardiac failure

Cardiac failure

AT

Complicated DAH-AT a

Complicated DAH-AT a

Etiologies

Classical DAH b

APS

Idiopathic DAH

Clinical findings

Shock

Oxygen index, MODS

P/F ratio

SAPS II, Oxygen flow, P/F ratio

Oxygen flow

Serum findings

Hb, LDH, eGFR

Lymphocytes

eGFR

BALF findings

Neutrophils, Lymphocytes

Others

Smoking (> 20 pack-years)

Multivariate analyses

 

Shock, LDH, eGFR

Classical DAH

P/F ratio, Simple, DAH-AT

Cardiac failure, APS, SAPS II, Oxygen flow

  1. AT antithrombotic therapy, APS Antiphospholipid syndrome, BALF bronchoalveolar lavage fluid, CVD cardiovascular disease, DAH diffuse alveolar hemorrhage, eGFR estimated glomerular filtration rate, Hb hemoglobin, IMV invasive mechanical ventilation, LDH lactate dehydrogenase, P/F partial pressure of arterial oxygen/fraction of inspiratory oxygen ratio, SAPS II Simplified Acute Physiology Score II
  2. aDAH occurred during antithrombotic therapy and had causes other than antithrombotic therapy
  3. bDAH associated with pulmonary vasculitis