Skip to main content

Table 4 Review of our and previous retrospective studies of prognostic factors in DAH

From: High neutrophils and low lymphocytes percentages in bronchoalveolar lavage fluid are prognostic factors of higher in-hospital mortality in diffuse alveolar hemorrhage

Authors (year) Prost [2] Rabe [3] Otoshi [9] Mirouse [5] Ours
Participants of studies
Patients number, n 97 37 76 104 68
Patients with AT, n Not described Not described 39 Not described 48
IMV, n (%) 17 (18%) 32 (86%) Not described 52 (50%) 38 (56%)
Mortality rate, n (%) 24 (25%) 19 (51%) 29 (38%) 16 (15%) 18 (27%)
Factors associated with mortality
Univariate analyses
Demographics Age Age
Comorbidities CVD Cardiac failure Cardiac failure
AT Complicated DAH-AT a Complicated DAH-AT a
Etiologies Classical DAH b APS Idiopathic DAH
Clinical findings Shock Oxygen index, MODS P/F ratio SAPS II, Oxygen flow, P/F ratio Oxygen flow
Serum findings Hb, LDH, eGFR Lymphocytes eGFR
BALF findings Neutrophils, Lymphocytes
Others Smoking (> 20 pack-years)
Multivariate analyses
  Shock, LDH, eGFR Classical DAH P/F ratio, Simple, DAH-AT Cardiac failure, APS, SAPS II, Oxygen flow
  1. AT antithrombotic therapy, APS Antiphospholipid syndrome, BALF bronchoalveolar lavage fluid, CVD cardiovascular disease, DAH diffuse alveolar hemorrhage, eGFR estimated glomerular filtration rate, Hb hemoglobin, IMV invasive mechanical ventilation, LDH lactate dehydrogenase, P/F partial pressure of arterial oxygen/fraction of inspiratory oxygen ratio, SAPS II Simplified Acute Physiology Score II
  2. aDAH occurred during antithrombotic therapy and had causes other than antithrombotic therapy
  3. bDAH associated with pulmonary vasculitis