Table 1 Baseline and clinical characteristics of the study population
Variables | Total (n = 602) | MP variation rate ≤ 0% (MP-worsened, n = 173) | MP variation rate > 0% (MP-improved, n = 429) | p |
|---|---|---|---|---|
Age, years | 61 (50, 70) | 62 (50, 70) | 61 (50, 69) | 0.500 |
Female, n (%) | 155 (26) | 33 (19) | 122 (28) | 0.023 |
Height, cm | 170 (165, 175) | 172 (165, 175) | 170 (163, 175) | 0.022 |
Weight, kg | 74 (65, 80) | 75 (67, 85) | 70 (63, 80) | 0.003 |
Admission type, n (%) | 0.425 | |||
Medical | 251 (42) | 77 (45) | 174 (41) | |
Surgical | 351 (58) | 96 (55) | 255 (59) | |
APACHE II score | 20 (15, 26) | 21 (16, 28) | 20 (15, 25) | 0.076 |
SOFA score | 10 (5, 13) | 10 (5, 14) | 10 (6, 13) | 0.608 |
Norepinephrine dose, µg/kg/min | 0.26 (0.10, 0.56) | 0.27 (0.11, 0.60) | 0.24 (0.10, 0.53) | 0.368 |
Respiratory treatment | ||||
Prone positioning, n (%) | 178 (30) | 68 (39) | 110 (26) | 0.001 |
NMBA, n (%) | 54 (9) | 28 (16) | 26 (6) | < 0.001 |
Ventilation mode | 0.231 | |||
Volume control, n (%) | 549 (91) | 154 (89) | 395 (92) | |
Pressure control, n (%) | 53 (9) | 19 (11) | 34 (8) | |
Baseline MP, J/min | 12.1 (10.8, 14.1) | 11.7 (10.8, 13.8) | 12.2 (10.9, 14.3) | 0.088 |
24-h MP, J/min | 10.7 (8.9, 13.3) | 14.2 (12.4, 16.4) | 9.7 (8.4, 11.3) | < 0.001 |
MP variation rate, % | 14 (− 3, 27) | − 14 (− 26, − 6) | 21 (12, 31) | < 0.001 |
ICU length of stay, days | 9 (5, 15) | 9 (5, 15) | 9 (5, 15) | 0.731 |
Hospital length of stay, days | 15 (10, 27) | 13 (9, 29) | 16 (10, 27) | 0.065 |
VFD at day 28, days | 16 (0, 22) | 10 (0, 21) | 16 (0, 22) | 0.007 |
ICU mortality, n (%) | 166 (28) | 62 (36) | 104 (24) | 0.005 |