Table 2 Interventions stratified by compliance groups
From: Trajectories of hypoxemia and pulmonary mechanics of COVID-19 ARDS in the NorthCARDS dataset
During the entire hospital stay | All patients with reliable compliance (n = 1536) | Patients with very low compliance (< 20 ml/cm H2O) (n = 531; 34.6%) | Patients with low–normal compliance (20–50 ml/cm H2O) (n = 970; 63.2%) | Patients with high compliance (> 50 ml/cm H2O) (n = 35; 2.2%) | p value (very low vs. low–normal compliance) |
|---|---|---|---|---|---|
Steroids* n (%) | 1272 (82.8%) | 461 (86.8%) | 781 (80.5%) | 30 (85.7%) | 0.002 |
Hydroxychloroquine n (%) | 1376 (89.6%) | 456 (85.9%) | 888 (91.5%) | 32 (91.4%) | < 0.001 |
Azithromycin n (%) | 958 (62.4%) | 268 (50.5%) | 667 (68.8%) | 23 (65.7%) | < 0.001 |
IL-1 or IL-6 inhibitor** n (%) | 474 (30.9%) | 188 (35.4%) | 274 (28.2%) | 12 (34.3%) | 0.004 |
Remdesivir n (%) | 11 (0.7%) | 4 (0.8%) | 7 (0.7%) | 0 (0.0%) | 0.945 |
Convalescent plasma n (%) | 109 (7.1%) | 46 (8.7%) | 62 (6.4%) | 1 (2.9%) | 0.104 |
Proning n (%) | 766 (49.9%) | 315 (59.3%) | 437 (45.1%) | 14 (40.0%) | < 0.001 |
Proning before intubation n (%) | 281 (18.3%) | 163 (30.7%) | 113 (11.6%) | 5 (14.3%) | < 0.001 |
Paralytics n (%)*** | 813 (52.9%) | 309 (58.2%) | 489 (50.4%) | 15 (42.9%) | 0.004 |
Vasopressors (y/n) in first 48 h post intubation n (%) | 1227 (79.9%) | 446 (84.0%) | 755 (77.8%) | 26 (74.3%) | 0.004 |
Inotropes (y/n) at any time count n (%) | 65 (4.2%) | 29 (5.5%) | 36 (3.7%) | 0 (0.0%) | 0.111 |
Median hours from hospital presentation to intubation (IQR) | 52.3 (7.8, 124.9) | 107.3 (25.8, 239.2) | 39.5 (5.4,91.6) | 31.4 (1.6,79.0) | < 0.001 |
CT pulmonary angiogram (CTPA) performed within [-1 to 7 days] of intubation n (%) | 48 (3.1%) | 21 (4.0%) | 26 (2.7%) | 1 (2.9%) | 0.175 |
Pulmonary embolus identified on CT n (% of patients with CTPA) | 6 (12.5%) | 2 (9.5%) | 3 (11.5%) | 1 (100.0%) | 0.824 |
Pre-intubation O2 supplementation n (%) **** | |||||
NRB | 1186 (77.2%) | 419 (78.9%) | 739 (76.2%) | 28 (80.0%) | 0.23 |
NRB + NC | 41 (2.7%) | 18 (3.4%) | 23 (2.4%) | 0 (0.0%) | 0.247 |
NC | 80 (5.2%) | 22 (4.1%) | 56 (5.8%) | 2 (5.7%) | 0.174 |
HFNC | 32 (2.1%) | 12 (2.3%) | 20 (2.1%) | 0 (0.0%) | 0.8 |
NIV (BiPAP/CPAP) | 52 (3.4%) | 23 (4.3%) | 28 (2.9%) | 1 (2.9%) | 0.14 |
Venturi | 16 (1.0%) | 2 (0.4%) | 14 (1.4%) | 0 (0.0%) | 0.054 |
Other***** | 129 (8.4%) | 35 (6.6%) | 90 (9.3%) | 4 (11.4%) | 0.072 |