Table 3 Oxygenation trends and duration of ventilation by compliance group
From: Trajectories of hypoxemia and pulmonary mechanics of COVID-19 ARDS in the NorthCARDS dataset
All patients with reliable compliance (n = 1536) | Patients with very low compliance (< 20 ml/cm H2O) (n = 531; 34.6%) | Patients with low–normal compliance (20–50 ml/cm H2O) (n = 970; 63.2%) | Patients with high compliance (> 50 ml/cm H2O) (n = 35; 2.2%) | p value (very low vs. low–normal compliance) | |
|---|---|---|---|---|---|
P/F derived pre intubation (12 h mean) | |||||
Mean (SD) | 93.39 (83.21) | 81.56 (75.24) | 100.55 (87.52) | 74.37 (45.05) | < 0.001 |
Median (IQR) | 60.00 (52.17,97.12) | 58.29 (50.21,70.73) | 61.84 (53.37, 117.66) | 58.84 (52.57,69.56) | |
n | 1437 | 498 | 907 | 32 | |
P/F from ABG pre intubation (12 h mean) | |||||
Mean (SD) | 107.09 (86.74) | 106.56 (97.26) | 108.43 (81.68) | 80.77 (22.83) | 0.829 |
Median (IQR) | 75.47 (61.73, 111.96) | 71.60 (59.26, 109.20) | 77.78 (63.76, 113.46) | 75.31 (66.05,97.22) | |
n | 453 | 163 | 279 | 11 | |
P/F derived post intubation, (12 h mean) | |||||
Mean (SD) | 67.19 (38.42) | 64.56 (36.30) | 68.49 (39.42) | 71.10 (40.67) | 0.058 |
Median (IQR) | 53.61 (40.99,80.13) | 52.89 (40.18,74.66) | 54.04 (41.40,83.63) | 58.80 (40.36,87.91) | |
n | 1533 | 531 | 967 | 35 | |
P/F from ABG post intubation (12 h mean) | |||||
Mean (SD) | 151.00 (74.45) | 139.88 (71.24) | 156.83 (75.60) | 160.74 (73.13) | < 0.001 |
Median (IQR) | 133.88 (95.50, 188.41) | 119.88 (92.00, 164.47) | 143.42 (98.28, 198.19) | 169.50 (95.00, 210.00) | |
n | 1476 | 515 | 928 | 33 | |
First ABG P/F post intubation (within 4 h after Ti) | |||||
Mean (SD) n | 142.91 (85.84) | 129.70 (77.54) | 150.22 (89.26) | 158.76 (95.74) | < 0.001 |
Median (IQR) | 119.00 (83.92, 179.00) | 103.50 (81.75, 156.25) | 125.00 (86.00, 194.50) | 130.00 (84.29, 249.00) | |
n | 1116 | 408 | 683 | 25 | |
P/F derived gradient 24 h pre intubation* | |||||
Mean (SD) | − 191.78 (1766.18) | − 213.06 (1230.52) | − 183.02 (2036.72) | − 94.58 (229.07) | 0.778 |
Median (IQR) | − 7.37 (− 104.95,1.24) | − 4.79 (− 29.15,1.37) | − 9.87 (− 144.38,0.94) | − 10.68 (− 93.17,4.32) | |
n | 1236 | 440 | 769 | 27 | |
Lactate pre intubation (24 h mean) | |||||
Mean (SD) | 1.88 (2.58) | 1.72 (1.74) | 2.11 (3.35) | 0.85 (0.31) | 0.300 |
Median (IQR) | 1.36 (1.00,1.85) | 1.40 (1.00,1.81) | 1.37 (0.97,1.90) | 0.85 (0.65,1.05) | |
n | 200 | 107 | 89 | 4 | |
Lactate post intubation (24 h mean) | |||||
Mean (SD) | 1.68 (1.61) | 1.84 (1.83) | 1.52 (1.30) | 0.73 (0.05) | 0.193 |
Median (IQR) | 1.30 (0.90,1.80) | 1.40 (0.90,1.85) | 1.30 (0.90,1.69) | 0.72 (0.70,0.76) | |
n | 184 | 103 | 77 | 4 | |
Number of hours with FiO2 ≥ 60% pre intubation | |||||
Mean (SD) | 64.63 (100.48) | 113.33 (135.88) | 37.91 (58.14) | 56.33 (110.16) | < 0.001 |
Median (IQR) | 23.32 (2.33,82.38) | 58.11 (8.50, 181.66) | 16.08 (1.17,46.11) | 15.50 (1.55,50.33) | |
n | 1473 | 514 | 927 | 32 | |
Proportion of time on FiO2 ≥ 60% pre–intubation | |||||
Mean (SD) | 62.5% (36.4%) | 68.7% (34.5%) | 58.7% (36.9%) | 67.6% (37.2%) | < 0.001 |
Median (IQR) | 74.4% (29.8%, 98.2%) | 85.0% (42.3%, 98.6%) | 65.7% (23.8%, 96.9%) | 84.8% (39.4%, 100.0%) | |
n | 1403 | 499 | 873 | 31 | |
Proportion of time on FiO2 ≥ 60% post–intubation | |||||
Mean (SD) | 52.3% (34.6%) | 54.9% (35.9%) | 50.9% (33.9%) | 52.3% (35.5%) | 0.032 |
Median (IQR) | 48.9% (18.8%, 88.9%) | 55.0% (18.6%, 94.6%) | 45.9% (19.0%, 84.9%) | 52.7% (17.3%, 87.7%) | |
n | 1536 | 531 | 970 | 35 | |
Oxygenation Index** | |||||
Mean (SD) | 11.30 (5.92) | 12.51 (6.15) | 10.68 (5.69) | 8.78 (4.93) | < 0.001 |
Median (IQR) | 10.26 (6.95,14.16) | 11.72 (8.32,15.52) | 9.56 (6.61,13.51) | 7.58 (6.25,10.68) | |
n | 1469 | 527 | 908 | 34 | |
PFP value*** | |||||
Mean (SD) | 144.86 (102.90) | 143.38 (93.86) | 146.24 (108.67) | 129.28 (63.09) | 0.61 |
Median (IQR) | 118.42 (84.00, 169.42) | 118.33 (84.21, 168.28) | 118.66 (83.92, 170.82) | 114.24 (83.10, 168.11) | |
n | 1530 | 531 | 964 | 35 | |
pH within –24 to + 4 h from Ti | |||||
Mean (SD) | 7.30 (0.12) | 7.26 (0.13) | 7.32 (0.11) | 7.33 (0.12) | < 0.001 |
Median (IQR) | 7.32 (7.22,7.39) | 7.28 (7.18,7.36) | 7.34 (7.26,7.40) | 7.35 (7.28,7.40) | |
n | 1119 | 410 | 686 | 23 | |
PaCo2 within –24 to + 4 h from Ti | |||||
Mean (SD) | 50.87 (17.37) | 57.95 (19.08) | 47.25 (15.21) | 42.50 (10.17) | < 0.001 |
Median (IQR) | 46.67 (39.00,59.00) | 54.00 (44.00,70.00) | 44.00 (37.60,53.00) | 40.00 (35.50,45.00) | |
n | 1201 | 419 | 753 | 29 |