Table 4 Mechanical ventilator obtained parameters (lung mechanics and ventilator settings)
From: Trajectories of hypoxemia and pulmonary mechanics of COVID-19 ARDS in the NorthCARDS dataset
All patients with reliable compliance (n = 1536) | Patients with very low compliance (< 20 ml/cm H2O) (n = 531; 34.6%) | Patients with low–normal compliance (20–50 ml/cm H2O) (n = 970; 63.2%) | Patients with high compliance (> 50 ml/cm H2O) (n = 35; 2.2%) | p–value (very low vs. low–normal compliance) | |
|---|---|---|---|---|---|
Compliance in the first 24 h of intubation | |||||
Mean (SD) | 24.57 (12.23) | 15.41 (3.26) | 27.67 (6.49) | 77.49 (30.27) | < 0.001 |
Median (IQR) | 22.65 (17.97,28.24) | 15.86 (13.26,18.26) | 25.63 (22.74,30.95) | 72.00 (54.36,89.90) | |
n | 1536 | 531 | 970 | 35 | |
Mean PEEP (cm H2O) within 24 h of intubation | |||||
Mean (SD) | 12.58 (3.75) | 11.67 (3.63) | 13.00 (3.68) | 14.65 (4.41) | < 0.001 |
Median (IQR) | 12.40 (10.00,15.00) | 11.45 (9.35,14.27) | 13.04 (10.00,15.22) | 15.00 (10.88,18.31) | |
n | 1536 | 531 | 970 | 35 | |
Mean Peak pressure (cm H2O) within 24 h of intubation | |||||
Mean (SD) | 32.86 (6.56) | 37.91 (6.18) | 30.38 (4.89) | 24.93 (5.29) | < 0.001 |
Median (IQR) | 32.41 (28.52,36.59) | 37.04 (34.08,41.65) | 30.39 (27.09,33.55) | 25.52 (22.78,27.16) | |
n | 1536 | 531 | 970 | 35 | |
Ventilation duration (days) | |||||
Mean (SD) | 15.26 (16.54) | 15.93 (18.18) | 14.81 (15.59) | 17.65 (16.27) | 0.211 |
Median (IQR) | 9.77 (4.35,19.85) | 10.06 (4.21,19.99) | 9.69 (4.43,19.24) | 9.56 (4.96,30.16) | |
n | 1536 | 531 | 970 | 35 | |
Ventilation duration (days) among those who survived | |||||
Mean (SD) | 19.95 (20.28) | 23.00 (23.87) | 18.64 (18.42) | 15.88 (13.15) | 0.030 |
Median (IQR) | 12.05 (5.16,29.13) | 13.44 (5.92,31.50) | 11.95 (4.55,27.72) | 10.62 (7.28,25.48) | |
n | 479 | 152 | 315 | 12 | |
Ventilation duration (days) among those who died | |||||
Mean (SD) | 13.07 (14.02) | 13.02 (14.40) | 12.90 (13.63) | 18.57 (17.89) | 0.902 |
Median (IQR) | 9.04 (4.10,17.53) | 8.48 (3.77,17.77) | 9.24 (4.33,16.91) | 8.71 (4.86,31.44) | |
n | 1057 | 379 | 655 | 23 | |
Vt cc/Kg of IBW within 24 h of intubation | |||||
Mean (SD) | 6.77 (1.16) | 6.80 (1.23) | 6.77 (1.14) | 6.46 (0.82) | 0.63 |
Median (IQR) | 6.63 (6.05,7.35) | 6.68 (6.05,7.38) | 6.62 (6.06,7.35) | 6.46 (6.01,6.91) | |
n | 1441 | 507 | 902 | 32 | |
Set respiratory rate (per minute) within 24 h of intubation | |||||
Mean (SD) | 24.23 (5.11) | 26.36 (5.24) | 23.15 (4.66) | 21.95 (4.66) | < 0.001 |
Median (IQR) | 24.09 (20.00,28.00) | 26.67 (22.53,30.04) | 23.48 (20.00,26.41) | 21.73 (19.00,25.30) | |
n | 1536 | 531 | 970 | 35 | |
Total respiratory rate within 24 h of intubation | |||||
Mean (SD) | 25.72 (4.75) | 27.64 (4.85) | 24.72 (4.38) | 24.30 (4.26) | < 0.001 |
Median (IQR) | 25.69 (22.25,29.20) | 28.00 (24.42,31.23) | 24.76 (21.60,27.84) | 24.00 (21.10,27.83) | |
n | 1536 | 531 | 970 | 35 | |
Plateau pressure (cm H2O) within 24 h of intubation | |||||
Mean (SD) | 28.37 (6.59) | 31.93 (6.60) | 26.05 (5.15) | 20.68 (8.11) | < 0.001 |
Median (IQR) | 28.00 (24.25,32.00) | 31.25 (27.50,35.80) | 26.00 (22.33,29.48) | 20.17 (16.25,27.75) | |
n | 1049 | 429 | 602 | 18 | |
Driving pressure* (cm H20) within 24 h of intubation | |||||
Mean (SD) | 16.18 (6.44) | 20.47 (6.82) | 13.31 (3.93) | 8.60 (5.32) | < 0.001 |
Median (IQR) | 15.00 (12.00,19.06) | 19.42 (16.00,24.08) | 13.00 (10.67,15.50) | 10.00 (4.62,11.33) | |
n | 1044 | 428 | 600 | 16 |