Fig. 6

Key driver analysis and kernel-based diffusion scores. A Probabilistic causal gene network projection and key driver analysis to identify causal regulators in the IPF disease module. Key driver genes (KDGs) and their neighbors are distinguished by color. B Fold change and false discovery rate of KDGs. C KDGs involving IPF-associated pathways (upper panel) and their diffusion scores (lower panel). D Current and investigational drugs for IPF and their molecular targets and diffusion scores. Diffusion scores were calculated using the z-scaled Monte-Carlo method based on the largest connected component of the disease module