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Table 4 Comparison of routine clinical examination values in patients with and without OSA

From: The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea

Variable

No OSA

OSA

P value

Numbers

105

35

NS

Age (years)*

37.06 ± 12.46

46.74 ± 14.25

0.001

Females (N%)*

87 (82.9%)

20 (57.1%)

< 0.001

BMI (kg·m−2)

22.32 ± 3.38

25.71 ± 4.13

0.154

SBP (mmHg)

111.28 ± 13.22

118.86 ± 14.71

0.004

DBP (mmHg)

72.26 ± 9.92

76.83 ± 14.79

0.006

NYHA (%)

  

0.327

 1

8 (7.6%)

0 (0%)

 

 2

46 (43.8%)

8 (22.9%)

 

 3

47 (44.8%)

26 (74.3%)

 

 4

4 (3.8%)

1 (2.9%)

 

Drug therapy

26/68/11

10/19/6

0.852

Targeting medication (none/single/combination)

   

Positive inotropes

79

21

0.206

Diuretics

94

20

0.335

Supplemental oxygen therapy

21

17

0.117

FEV1

78.67 ± 14.87

74.28 ± 13.60

0.783

FVC

86.13 ± 16.75

84.35 ± 14.28

0.671

FEV1/FVC

94.33 ± 7.82

92.66 ± 8.43

0.562

TLC

83.91 ± 9.65

79.37 ± 8.52

0.942

DLCO

72.75 ± 11.68

70.42 ± 14.72

0.923

PaO2 (mmHg)*

71.77 ± 15.21

63.69 ± 10.21

0.014

PaCO2 (mmHg)

35.76 ± 4.74

36.51 ± 11.17

0.843

SaO2 (%)

93.24 ± 4.71

91.79 ± 3.77

0.199

Epworth score

3.34 ± 3.12

4.67 ± 2.97

0.740

LA (mm)

30.99 ± 6.27

33.2 ± 6.30

0.4433

LV (mm)

37.36 ± 6.79

41.11 ± 7.36

0.609

LVEF (%)

63.02 ± 5.65

61.97 ± 6.54

0.337

RV (mm)

32.27 ± 6.82

33.8 ± 7.71

0.306

sPAP (mmHg)

88.88 ± 22.90

85.52 ± 17.66

0.321

6MWD (m)

418.66 ± 96.40

368.56 ± 120.62

0.337

NT-proBNP (pg/ml)

1126.31 ± 1298.81

1662.47 ± 1493.71

0.553

mPAP (mmHg)*

56.45 ± 18.19

53.57 ± 13.08

0.010

PVR (dyn•s•cm−5)

1110.86 ± 517.33

1181.54 ± 402.09

0.071

CI (L/min/m2)

3.04 ± 1.34

2.04 ± 1.11

0.730

MRAP (mmHg)

5.97 ± 4.67

6.11 ± 3.89

0.465

Peak VO2/kg (ml/kg/min)

13.16 ± 3.95

11.08 ± 3.46

0.272

VE/VCO2

42.27 ± 9.21

45.19 ± 11.29

0.380

VE/VCO2 slope

43.33 ± 15.41

48.48 ± 15.19

0.860

  1. Data are presented as mean ± SD or median (interquartile range). BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; NYHA, New York Heart Association; FEV1, forced expiratory volume at first second; FVC, forced vital capacity; TLC, total lung capacity; DLCO, diffusion capacity for carbon monoxide of the lung; PaO2, arterial oxygen pressure (daytime); PaCO2, arterial carbon dioxide pressure (daytime); SaO2, arterial oxygen saturation (daytime); LA, anteroposterior diameter of left atrium; LV, anteroposterior diameter of left ventricle; LVEF, left ventricular ejection fraction; RV, right ventricular end-diastolic diameter; sPAP, pulmonary artery systolic pressure; 6MWD, six-minute walking distance; NT-proBNP, N-terminal pro B type natriuretic peptide; MPAP, mean pulmonary arterial pressure; PVR, pulmonary vascular resistance; CI, cardiac index; MRAP, mean right atrial pressure; PeakVO2/kg, peak kilogram oxygen uptake; VE/VCO2, carbon dioxide ventilation equivalent; VE/VCO2 slope: the slope of carbon dioxide ventilation equivalent