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Table 1 Base case

From: Cost-utility of as-needed ICS-formoterol versus to maintenance ICS in mild to moderate persistent asthma

Variable Base case Valor high Valor low References
Cost US$
 Cost Budesonide-Formoterol (per 120 doses) $53 $66 $40  
 Cost controlled (anual) $416 $520 $312 [17]
 Cost mild exacerbation (per episode) $94 $118 $71  
 Cost moderate exacerbation (per episode) $191 $239 $143  
 Cost severe exacerbation (per episode) $386 $483 $290  
Utilities (anual)
 Controlled asthma 0.92 1 0.69  
 Exacerbation with OCS Burst 0.86 1 0,65 [13]
 Exacerbation with ED visit 0,83 1 0,62  
 Exacerbation with Hospitalization 0.74 0.93 0.56  
Budesonide + Formoterol efect
 Relative risk on exacerbation rate 0.85 0.72 1  
 Relative risk on ED visit 0.65 0.43 0.98 [9]
 Adherence to as need—budesonide-formoterol 68% 85% 51% [10]
 Adherence to IC daily 62% 78% 47% [10]
 As-Needed budesonide-formoterol by Time of Day 0.52 0.65 0.39  
Transition probabilities
 Probability controlled to OC Burst 0.11 0.14 0.10  
 Probability OCS Burst to ED visit 0.02 0.03 0.02 [12]
 Probability of ED visti to hospitalization 0.0117 0.01 0.01  
 Asthma mortality 0.0000020 0.00 0.00  
 Annual dicount rate 5% 6% 0%