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Table 1 Comparison of general characteristics of patients between two groups (Mean ± SD)

From: Predictors and outcomes of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in China

Variables COPD group (N = 648)    COPD overlap OSA group(N = 194)    χ2/t value P
  AHI < 5 events / h 5 events / h ≤ AHI < 15 events / h Total 15 events / h ≤ AHI < 30 events / h AHI ≥ 30 events / h Total   
Gender (male,%) 200(69.93%) 253(69.89%) 453(69.91%) 87(70.73%) 54(76.06%) 141(72.68%) 0.427 0.513
Age y (mean ± SD) 62 ± 7 64 ± 9 63 ± 8 63 ± 9 64 ± 9 62 ± 7 1.57 0.117
BMI (kg/m2) (mean ± SD) 21 ± 3 22 ± 4 22 ± 4 23 ± 4 24 ± 4 24 ± 4  − 6.11  < 0.001
Neck circumference (cm) (mean ± SD) 36.5 ± 2.2 37.3 ± 3.1 37.0 ± 2.6 37.5 ± 35 38.6 ± 3.6 38.1 ± 3.5 3.97  < 0.001
Smoking index (package year) 32.5 ± 27.8 37.5 ± 27.0 35.5 ± 27.5 38.5 ± 25.5 40.5 ± 22.6 39.2 ± 24.8  − 1.68 0.093
Smoke status(never,%) 123(43.01%) 133(36.74%) 248(38.27%) 42(34.15%) 25(35.21%) 67(34.54%) 5.53 0.06
FEV1 (L) (mean ± SD) \ 1.1 ± 0.8 1.0 ± 0.8 1.2 ± 1.0 1.4 ± 1.3 1.3 ± 1.1  − 4.18  < 0.001
FEV1% of expected value (mean ± SD) 42.0 ± 28.5 45.5 ± 30.0 44.5 ± 29.5 52.5 ± 32.6 60.0 ± 39.5 55.0 ± 36.5  − 4.11  < 0.001
FEV1% of predicted value < 50% ( n) 169(59.09%) 190(52.49%) 359(55.40%) 51(41.46%) 24(33.80%) 75(38.66%) 10.047 0.002
FEV1/FVC(%) 38.0 ± 21.0 40.0 ± 20.0 39.0 ± 21.0 43.0 ± 23.0 55.0 ± 25.0 49.0 ± 240  − 5.624  < 0.001
AHI (events / h) 2.5 ± 2.2 9.1 ± 5.2 6.2 ± 5.7 19.8 ± 7.3 37.8 ± 20.0 26.7 ± 14.7  − 28.987  < 0.001
Acute exacerbation in the past year (frequency) 2.1 ± 1.5 2.2 ± 2.1 2.1 ± 2.0 2.1 ± 2.0 2.1 ± 2.0 2.0 ± 2.1 0.60 0.546
Hospitalization in the past year (frequency) 0.5 ± 1.1 1.3 ± 2.2 1.3 ± 1.5 1.2 ± 2.1 1.1 ± 2.0 1.2 ± 2.0 0.75 0.453
mMRC scores (mean ± SD) 2.0 ± 0.4 1.0 ± 2.2 1.5 ± 1.3 1.8 ± 2.0 1.5 ± 1.3 1.6 ± 1.1  − 0.97 0.331
CAT scores (mean ± SD) 14.7 ± 6.5 16.8 ± 7.3 15.9 ± 7.2 17.3 ± 8.2 19.2 ± 8.4 18.4 ± 8.4  − 4.08  < 0.001
ESS scores (mean ± SD) 4.1 ± 4.0 5.2 ± 4.1 5.1 ± 4.0 6.2 ± 5.1 8.1 ± 9.0 7.8 ± 5.9  − 7.32  < 0.001
SBQ scores(mean ± SD) 3.1 ± 2.0 4.4 ± 3.2 4.2 ± 3.0 5.5 ± 4.0 7.0 ± 4.0 6.0 ± 4.0  − 7.50  < 0.001
HADS-A scores 4.5 ± 3.2 6.5 ± 4.1 5.7 ± 3.8 7.6 ± 4.0 10.5 ± 7.5 9 .3 ± 6.1  − 9.92  < 0.001
HADS-D scores 4.4 ± 2.7 6.3 ± 4.3 5.5 ± 3.6 7.2 ± 4.5 11.0 ± 7.2 9.5 ± 6.4  − 11.10  < 0.001
CCI scores (mean ± SD) 2.0 ± 1.0 3.0 ± 2.0 2.7 ± 1.4 3.0 ± 1.5 4.0 ± 2.0 3.4 ± 1.7 0 1
Hypertension (n,%) 71(24.83%) 119(32.87%) 190(29.32%) 52(42.28%) 41(57.75%) 93(47.94%) 8.001 0.005
Cor Pulmonale (n,%) 15(5.24%) 22(6.08%) 37(5.71%) 9(7.32%) 6(8.45%) 15(7.73%) 0.937 0.333
Coronary heart disease(n,%) 22(7.69%) 45(12.43%) 67(10.34%) 14(11.38%) 6(8.45%) 20(10.31%) 7.305 0.007
Diabetes (n,%) 15(5.24%) 61(16.85%) 76(11.73%) 24(19.51%) 20(28.17%) 44(22.68%) 13.845  < 0.001
  1. Gender, FEV1% of predicted value < 50%, Hypertension, cor pulmonale,coronary heart disease and diabetes are presented as n; other values are the mean with SD; COPD chronic obstructive pulmonary disease; OSA obstructive sleep apnea; SD standard deviation; BMI body mass index; FEV1 forced expiratory volume in 1 s; FVC forced vital capacity; AHI apnea–hypopnea index; mMRC Modified British Medical Research Council; CAT COPD assessment test; ESS Epworth sleepiness scale; CCI Charlson comorbidity index; SBQ STOP-Bang; HADS-A Hospital Anxiety and Depression Scale for anxiety; HADS-D Hospital Anxiety and Depression Scale for depression