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Table 1 Comparison of general characteristics of patients between two groups (Mean ± SD)

From: Predictors and outcomes of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in China

Variables

COPD group (N = 648)

  

COPD overlap OSA group(N = 194)

  

χ2/t value

P

 

AHI < 5 events / h

5 events / h ≤ AHI < 15 events / h

Total

15 events / h ≤ AHI < 30 events / h

AHI ≥ 30 events / h

Total

  

Gender (male,%)

200(69.93%)

253(69.89%)

453(69.91%)

87(70.73%)

54(76.06%)

141(72.68%)

0.427

0.513

Age y (mean ± SD)

62 ± 7

64 ± 9

63 ± 8

63 ± 9

64 ± 9

62 ± 7

1.57

0.117

BMI (kg/m2) (mean ± SD)

21 ± 3

22 ± 4

22 ± 4

23 ± 4

24 ± 4

24 ± 4

 − 6.11

 < 0.001

Neck circumference (cm) (mean ± SD)

36.5 ± 2.2

37.3 ± 3.1

37.0 ± 2.6

37.5 ± 35

38.6 ± 3.6

38.1 ± 3.5

3.97

 < 0.001

Smoking index (package year)

32.5 ± 27.8

37.5 ± 27.0

35.5 ± 27.5

38.5 ± 25.5

40.5 ± 22.6

39.2 ± 24.8

 − 1.68

0.093

Smoke status(never,%)

123(43.01%)

133(36.74%)

248(38.27%)

42(34.15%)

25(35.21%)

67(34.54%)

5.53

0.06

FEV1 (L) (mean ± SD)

\

1.1 ± 0.8

1.0 ± 0.8

1.2 ± 1.0

1.4 ± 1.3

1.3 ± 1.1

 − 4.18

 < 0.001

FEV1% of expected value (mean ± SD)

42.0 ± 28.5

45.5 ± 30.0

44.5 ± 29.5

52.5 ± 32.6

60.0 ± 39.5

55.0 ± 36.5

 − 4.11

 < 0.001

FEV1% of predicted value < 50% ( n)

169(59.09%)

190(52.49%)

359(55.40%)

51(41.46%)

24(33.80%)

75(38.66%)

10.047

0.002

FEV1/FVC(%)

38.0 ± 21.0

40.0 ± 20.0

39.0 ± 21.0

43.0 ± 23.0

55.0 ± 25.0

49.0 ± 240

 − 5.624

 < 0.001

AHI (events / h)

2.5 ± 2.2

9.1 ± 5.2

6.2 ± 5.7

19.8 ± 7.3

37.8 ± 20.0

26.7 ± 14.7

 − 28.987

 < 0.001

Acute exacerbation in the past year (frequency)

2.1 ± 1.5

2.2 ± 2.1

2.1 ± 2.0

2.1 ± 2.0

2.1 ± 2.0

2.0 ± 2.1

0.60

0.546

Hospitalization in the past year (frequency)

0.5 ± 1.1

1.3 ± 2.2

1.3 ± 1.5

1.2 ± 2.1

1.1 ± 2.0

1.2 ± 2.0

0.75

0.453

mMRC scores (mean ± SD)

2.0 ± 0.4

1.0 ± 2.2

1.5 ± 1.3

1.8 ± 2.0

1.5 ± 1.3

1.6 ± 1.1

 − 0.97

0.331

CAT scores (mean ± SD)

14.7 ± 6.5

16.8 ± 7.3

15.9 ± 7.2

17.3 ± 8.2

19.2 ± 8.4

18.4 ± 8.4

 − 4.08

 < 0.001

ESS scores (mean ± SD)

4.1 ± 4.0

5.2 ± 4.1

5.1 ± 4.0

6.2 ± 5.1

8.1 ± 9.0

7.8 ± 5.9

 − 7.32

 < 0.001

SBQ scores(mean ± SD)

3.1 ± 2.0

4.4 ± 3.2

4.2 ± 3.0

5.5 ± 4.0

7.0 ± 4.0

6.0 ± 4.0

 − 7.50

 < 0.001

HADS-A scores

4.5 ± 3.2

6.5 ± 4.1

5.7 ± 3.8

7.6 ± 4.0

10.5 ± 7.5

9 .3 ± 6.1

 − 9.92

 < 0.001

HADS-D scores

4.4 ± 2.7

6.3 ± 4.3

5.5 ± 3.6

7.2 ± 4.5

11.0 ± 7.2

9.5 ± 6.4

 − 11.10

 < 0.001

CCI scores (mean ± SD)

2.0 ± 1.0

3.0 ± 2.0

2.7 ± 1.4

3.0 ± 1.5

4.0 ± 2.0

3.4 ± 1.7

0

1

Hypertension (n,%)

71(24.83%)

119(32.87%)

190(29.32%)

52(42.28%)

41(57.75%)

93(47.94%)

8.001

0.005

Cor Pulmonale (n,%)

15(5.24%)

22(6.08%)

37(5.71%)

9(7.32%)

6(8.45%)

15(7.73%)

0.937

0.333

Coronary heart disease(n,%)

22(7.69%)

45(12.43%)

67(10.34%)

14(11.38%)

6(8.45%)

20(10.31%)

7.305

0.007

Diabetes (n,%)

15(5.24%)

61(16.85%)

76(11.73%)

24(19.51%)

20(28.17%)

44(22.68%)

13.845

 < 0.001

  1. Gender, FEV1% of predicted value < 50%, Hypertension, cor pulmonale,coronary heart disease and diabetes are presented as n; other values are the mean with SD; COPD chronic obstructive pulmonary disease; OSA obstructive sleep apnea; SD standard deviation; BMI body mass index; FEV1 forced expiratory volume in 1 s; FVC forced vital capacity; AHI apnea–hypopnea index; mMRC Modified British Medical Research Council; CAT COPD assessment test; ESS Epworth sleepiness scale; CCI Charlson comorbidity index; SBQ STOP-Bang; HADS-A Hospital Anxiety and Depression Scale for anxiety; HADS-D Hospital Anxiety and Depression Scale for depression
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BMC Pulmonary Medicine

ISSN: 1471-2466

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