Fig. 3
From: GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells
GLP2R expression. The protein expression of in parent or drug-resistant PC9 (A) and HCC827 (B) cells. C, D GLP2R expression in parental cells was up-regulated by overexpression plasmid transfection (PC-GLP2R-OV or HCC287-GLP2R-OV). E, F GLP2R expression in drug-resistant cell lines was down-regulated by siRNA transfection (PC-XR + GLP2R-KD or HCC287-XR + GLP2R-KD). The parent cells, PC or HCC287; parental cells exogenously express GLP2R, GLP2R-OV; PC9 or HCC827 cells resistant to dacomitinib (PC-DR or HCC287-DR), osimertinib (PC-OR or HCC287-OR) or afatinib (PC-AR or HCC287-AR); knockdown of GLP2R levels in drug-resistant cell, GLP2R-KD. *P < 0.05