Fig. 4
From: GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells
GLP2-GLP2R signal affects the sensitivity of PC9 and HCC827 cells to EGFR-TKIs. The cell survival of parent or drug- resistant PC9 (A) and HCC827 (B) cells transfected with pcDNA3.1-GLP2R plasmid or siRNA-GLP2R. The cell survival of PC9 (C) and HCC827 (D) cells treated with teduglutide (0.5 μM). The parent cells, PC or HCC287; parental cells exogenously express GLP2R, PC-GLP2R or HCC287-GLP2R; PC9 or HCC827 cells resistant to dacomitinib (PC-DR or HCC287-DR), osimertinib (PC-OR or HCC287-OR) or afatinib (PC-AR or HCC287-AR); knockdown of GLP2R levels in drug-resistant cell, PC-XR + GLP2R-KD or HCC287-XR + GLP2R-KD. *P < 0.05