Fig. 5
From: GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells
GLP2-GLP2R signal is involved in the cisplatin resistance mechanism of A549 cells. A The protein expression of GLP2R in A549 and A549/DDP cells. GLP2R expression in A549 cells was up-regulated by overexpression plasmid transfection (B), in A549/DDP cells was down-regulated by siRNA transfection (C). The cell survival (D) and apoptosis (E) of A549 and A549/DDP cells transfected with pcDNA3.1-GLP2R plasmid or siRNA-GLP2R. The cell survival (F) and apoptosis (G) of A549 and A549/DDP cells treated with teduglutide (0.5 μM). *P < 0.05