Table 4 Univariable and multivariable Cox proportional hazards regression analysis of all-cause mortality predictors in patients with fibrotic hypersensitivity pneumonitis (N = 88)
Characteristic | HR (95% CI) | P value | HR¶ (95% CI) | P value |
|---|---|---|---|---|
Age* | 1.07 (1.02–1.11) | 0.0003 | 1.09 (1.04–1.14) | 0.0002 |
Male sex | 1.42 (0.75–2.71) | 0.276 | – | – |
Ever smoker | 1.60 (0.83–3.08) | 0.165 | – | – |
Any identifiable exposure history | 0.68 (0.35–1.29) | 0.241 | ||
TLC%* | 0.98 (0.96–1.01) | 0.147 | – | – |
FVC%* | 0.99 (0.98–1.02) | 0.786 | – | – |
DLCO%* | ||||
Any positive HP serology (excluding those not done, N = 12) | 1.34 (0.68–2.67) | 0.398 | – | – |
BALL %* | 0.97 (0.95–0.99) | 0.004 | 0.98 (0.96–0.99) | 0.015 |
BAL lymphocytosis ≥ 30% | 0.431 (0.19–0.95) | 0.027 | 0.47 (0.21–1.08) | 0.058 |
GGO | 0.75 (0.37–1.56) | 0.466 | – | – |
Mosaic attenuation | 0.67 (0.36–1.29) | 0.238 | – | – |
Centrilobular nodules | 0.27 (0.08–0.89) | 0.011 | 0.31 (0.09–1.02) | 0.054 |
Honeycombing | 2.65 (1.23–5.70) | 0.012 | 2.64 (1.15–6.06) | 0.022 |