Table 4 Logistic regression model for emphysema

rs2070600 = CC

 Age

1.02 (0.98–1.05)

1.00 (0.96–1.05)

 Sex

Male vs. Female (ref.)

10.04 (4.18–24.12)

5.40 (1.53–19.11)

 Smoking status

Current vs. None (ref.)

5.85 (2.73–12.55)

0.85 (0.27–2.62)

Former vs. None (ref.)

7.63 (3.78–15.40)

2.03 (0.73–5.62)

 Income

 ≤ 49 vs. ≥ 100 (ref.)

1.33 (0.72–2.45)

50–99 vs. ≥ 100 (ref.)

1.74 (0.77–3.89)

 Education

 < Elementary vs. high (ref.)

0.38 (0.19–0.77)

Elementary vs. high (ref.)

0.59 (0.30–1.15)

Middle vs. high (ref.)

0.46 (0.20–1.10)

 BMI

0.79 (0.72–0.87)

0.79 (0.70–0.88)

 COPD

Yes vs. No (ref.)

4.39 (2.39–8.06)

2.97 (1.53–5.79)

 Diabetes

Yes vs. No (ref.)

0.65 (0.31–1.38)

 Kidney disease

Yes vs. No (ref.)

0.01 (0.001–999.9)

 CVD*

Yes vs. No (ref.)

0.71 (0.31–1.61)

 Log sRAGE

0.23 (0.12–0.44)

0.24 (0.11–0.51)

rs2070600 = TC + TT

 Age

1.01 (0.96–1.06)

1.02 (0.95–1.09)

 Sex

Male vs. Female (ref.)

10.00 (0.01–35.82)

5.11 (0.01–21.99)

 Smoking status

Current vs. None (ref.)

10.54 (2.88–38.57)

1.54 (0.33–7.14)

Former vs. None (ref.)

10.41 (3.33–32.54)

1.65 (0.42–6.41)

 Income

 ≤ 49 vs. ≥ 100 (ref.)

0.38 (0.15–0.97)

50–99 vs. ≥ 100 (ref.)

0.46 (0.14–1.52)

 Education

 < Elementary vs. high (ref.)

0.10 (0.03–0.36)

Elementary vs. high (ref.)

0.29 (0.11–0.77)

Middle vs. high (ref.)

0.79 (0.21–3.03)

 BMI

0.77 (0.67–0.88)

0.77 (0.65–0.91)

 COPD

Yes vs. No (ref.)

6.27 (2.43–16.20)

4.46 (1.58–12.58)

 Diabetes

Yes vs. No (ref.)

1.01 (0.41–2.51)

 Kidney disease

Yes vs. No (ref.)

4.00 (0.85–18.88)

 CVD

Yes vs. No (ref.)

0.47 (0.15–1.47)

 Log sRAGE

0.77 (0.35–1.70)

0.61 (0.23–1.61)