Bacterial and viral coinfection in idiopathic pulmonary fibrosis patients: the prevalence and possible role in disease progression

Table 2 Comparison of pulmonary function indices between non-infected, bacterial-, viral- and co-infected IPF patients, respectively

PFT index	Non-infected Group 1 (n = 8)	Bacterial Infection Group 2 (n = 7)	Viral Infection Group 3 (n = 12)	Coinfection Group 4 (n = 40)	R, Adj. p*	R, Adj. p⁺	R, Adj. p^$
FVC	79.7 ± 3.30	76.6 ± 5.19	77.8 ± 2.88	73.7 ± 4.08	0.961, 0.368	0.976, 0.652	0.924, 0.013
FEV₁	73.5 ± 5.0	73.1 ± 5.55	73.1 ± 3.39	69.5 ± 3.82	0.994, 0.996	0.994, 0.992	0.945, 0.152
DL_CO	76.5 ± 1.29	71.7 ± 4.64	71.2 ± 2.73	69.3 ± 3.70	0.937, 0.076	0.93, 0.030	0.905, 0.001

Data represents Mean ± SD
IPF uninfected patients are considered as the reference group (Group 1). The Adj. P is based on the marginally adjusted p values by the Benjamini–Hochberg-FDR correction at α = 0.05. Bold values indicated as statistically significant at p < 0.05 level
PFT pulmonary function test, R ratio
^*Comparison between group 2 versus group 1
⁺Comparison between group 3 versus group 1
^$Comparison between group 4 versus group 1

ISSN: 1471-2466