Table 1 Demographic and clinical characteristics of the subjects enrolled in this study
From: Respiratory MUC5B disproportion is involved in severe community-acquired pneumonia
Characteristic | NSCAP | SCAP | p value |
|---|---|---|---|
Demographics | |||
N | 73 | 45 | Â |
Age (years) | 50.9 ± 14.1 | 56.2 ± 16.7 | 0.068 |
Gender, male (%) | 42 (57.5%) | 18 (40.0%) | 0.064 |
Symptoms and CURB-65 score | |||
Cough | 62 (84.9%) | 40 (88.9%) | 0.542 |
Sputum | 54 (74%) | 36 (80%) | 0.455 |
Difficulty breathing | 14 (19.2%) | 22 (48.9%) | 0.001 |
Fever | 35 (47.9%) | 24 (53.3%) | 0.570 |
CURB-65 score | |||
 0 | 57 (78.1%) | 20 (44.4%) | < 0.001 |
 1 | 15 (20.5%) | 14 (31.1%) | |
 2 | 1 (1.4%) | 8 (17.8%) | |
 3 | 0 (0%) | 2 (4.4%) | |
 4 | 0 (0%) | 1 (2.2%) | |
 5 | 0 (0%) | 0 (0%) | |
Comorbid conditions | |||
Current or ex-smoker | 21 (28.8%) | 6 (13.3%) | 0.053 |
Hypertension | 15 (20.5%) | 15 (33.3%) | 0.121 |
Diabetes mellitus | 9 (12.3%) | 6 (13.3%) | 0.874 |
Chronic cardiac disease | 1 (1.4%) | 1 (2.2%) | 0.728 |
Prior malignancy | 5 (6.8%) | 0 (0%) | 0.073 |
Immune disorder | 0 (0%) | 1 (2.2%) | 0.201 |
Inflammatory biomarkers in Peripheral blood | |||
WBC (109/l) | 6.1 (4.9–8.0) | 6.5 (5.2–8.1) | 0.814 |
NEUT (%) | 64.6 (54.6–73.4) | 71.0 (61.3–78.0) | 0.028 |
LYM (%) | 26.7 (18.3–35.2) | 19.6 (16.4–30.0) | 0.028 |
MO (%) | 6.0 (5.0–7.3) | 5.7 (4.5–7.9) | 0.459 |
EO (%) | 1.5 (0.7–2.6) | 1.6 (0.7–2.4) | 0.934 |
PLT (109/l) | 230 (178.5–269.5) | 229 (168.5–249.5) | 0.458 |
LDH (U/l) | 108.0 (20.8–177.0) | 203.0 (177.5–231.0) | < 0.001 |
CRP (mg/l) | 3.8 (0.6–29.0) | 16.0 (2.4–56.7) | 0.024 |
ESR (mm/h) | 21.0 (8.0–32.0) | 56.5 (37.8–87.3) | < 0.001 |
Fib (g/l) | 3.3 (2.4–5.1) | 4.4 (3.2–5.9) | 0.012 |
D-D (mg/l) | 0.3 (0.1–0.7) | 0.6 (0.4–1.2) | 0.002 |