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Table 4 Risk of severe asthma exacerbation of antipsychotics with high blocking affinity of receptor

From: Typical antipsychotics is associated with increased risk of severe exacerbation in asthma patients: a nationwide population-based cohort study

Characteristics Number (%) Conditional logistic regression P value
Case period Control period Crude OR
(95% CI)
P value Adjusted ORa
(95% CI)
No antipsychotics use 17,927 18,037 Ref   Ref  
Antipsychotics with high blocking affinityb,c       
 β2 adrenergic receptor 302 (1.7) 276 (1.5) 1.37 (0.98–1.92) 0.064 1.25 (0.87–1.81) 0.227
 M2 muscarinic receptor 442 (2.4) 356 (1.9) 1.60 (1.29–1.99) < 0.001 1.39 (1.10–1.76) 0.007
 D1 dopaminergic receptor 391 (2.1) 357 (1.9) 1.34 (1.04–1.73) 0.025 1.17 (0.88–1.55) 0.283
 D2 dopaminergic receptor 535 (2.9) 440 (2.4) 1.52 (1.26–1.84) < 0.001 1.33 (1.08–1.63) 0.008
  1. aAdjusted for heart failure, ischemic heart disease, stroke, gastroesophageal reflux disease, obesity disorder, rhinosinusitis, schizophrenia, pneumonia, acute upper airway infection, antiplatelet agents, cardioselective β-blocker, non-selective β-blocker, NSAID, anti-psychotics, anti-depressants, bladder anticholinergic agents, gastrointestinal tract anticholinergic agents, first generation anti-histamine, second/third generation anti-histamine, short-acting beta-agonist, short-acting muscarinic antagonist, short-acting beta-agonist plus short-acting muscarinic antagonist, long-acting beta-agonist plus long-acting beta-agonist, long-acting beta-agonist, xanthine inhibitor, leukotriene receptor antagonist
  2. bHigh blocking affinity is defined as Ki value < 100 (see Additional file 1: Table S4)
  3. cAntipsychotics without Ki (inhibitory constant) value were excluded from analysis