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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Notch1 activation of Jagged1 contributes to differentiation of mesenchymal stem cells into endothelial cells under cigarette smoke extract exposure

Fig. 5

Jagged1 promotes endothelial cell (ECs) differentiation, which is dependent on endogenous Notch1 signaling. A, B Jagged1-Fc-activated Notch1 signaling in mesenchymal stem cells (MSCs), as shown by the upregulated protein expression of N1ICD and Hey1; this response was blocked by Notch1-shRNA2. C–H Jagged1 enhanced the expression levels of CD31, eNOS, VE-cadherin and VEGFR2; however, a significant reversal of this effect was observed when induced cells were transfected with Notch1-shRNA2 lentivirus. *P < 0.05

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BMC Pulmonary Medicine

ISSN: 1471-2466

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