Fig. 2

A Active Ras was significantly increased in WT (p = 0.01), RAGE TG (p = 0.01) and RAGE KO mice (p = 0.02) exposed to SHS compared to RA controls. Active Ras in SHS-exposed RAGE KO mice (^) was significantly less than SHS-exposed WT (p = 0.03) or RAGE TG (p = 0.02) mice. Data are representative of experiments (n = 6 mice per group). B Active NF-κB was significantly elevated in WT (p = 0.01), RAGE TG (p = 0.01), and RAGE KO (p = 0.04) mice exposed to SHS compared to RA counterparts. Active NF-κB in SHS-exposed RAGE KO mice (^) was significantly less than SHS-exposed WT (p = 0.03) or RAGE TG (p = 0.03) mice. Data are representative of experiments (n = 6 mice per group)