Fig. 5
Lung physiology was evaluated in mice in order to determine alterations in mechanics. WT mice experienced significantly diminished FVC (Forced Vital Capacity, p = 0.03) (A) and FEV0.1 (Forced Expiratory Volume at 0.1 s, p = 0.04) (B) following SHS exposure. FEV at PEF (Peak Expiratory Flow) was also significantly diminished in WT mice exposed to SHS compared to RA controls (C, p = 0.03). RAGE KO animals were resistant to SHS-induced changes in FVC (A), FEV0.1 (B), and FEV at PEF (C). Evaluations were obtained in mice attached to the FlexiVent Instrument (Scireq) (n = 6 animals per group)