Fig. 5

Treatment with dapagliflozin attenuated the expression of NLRP3, IL-1β and IL-18 in MCT-injected rats (n = 3). Western blotting and quantification analysis of NLRP3 (A), IL-18 (B), IL-1β (C) and β-actin (loading control) in lung tissue from different groups. The samples were derived from the same experiment, and the gels/blots were processed in parallel. The gels/blots were corpped, full-length gels/blots are presented in Additional file 2: Figure S2, Additional file 3: Figure S3, and Additional file 4: Figure S4. Quantification of plasma levels of IL-18 (D) and IL-1β (E). Values are means ± SD. Comparisons were made by the Student’s t-test. Dapa, dapagliflozin; MCT, Monocrotaline; Veh, vehicle; Silde, sildenafil. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus MCT rats treated with vehicle