Table 1 Clinical characteristics of the MAC alone and co-infection groups
Characteristic | Total | MAC alone group | Co-infection group | p value |
|---|---|---|---|---|
No. of patients | 48 | 36 | 12 | |
Age: (years); median (range)a | 71 (63.8–78) | 71 (62–78) | 71.5 (67.8–75.8) | 0.195 |
Gender: female; n (%) | 39 (81.3) | 29 (80.6) | 10 (83.3) | > 0.999 |
BMI: (kg/m2); median (range)a | 19 (16.3–21) | 19 (17.3–21.3) | 18.3 (16.2–19.5) | 0.301 |
Smoking: never; n (%) | 35 (72.9) | 25 (69.4) | 10 (83.3) | 0.469 |
Positive result for GPL-core serum IgA; n (%) | 38 (79.2) | 28 (77.8) | 10 (83.3) | > 0.999 |
Comorbidities; n (%) | ||||
Rheumatoid arthritis (RA) | 10 (20.8) | 8 (22.2) | 2 (16.7) | > 0.999 |
Sinusitis | 4 (8.3) | 3 (8.3) | 1 (8.3) | > 0.999 |
Underlying pulmonary disease; n (%) | ||||
Emphysema | 6 (12.5) | 5 (13.9) | 1 (8.3) | > 0.999 |
Interstitial pneumonia | 8 (16.7) | 7 (19.4) | 1 (8.3) | 0.659 |
Concomitant drug; n (%) | ||||
Corticosteroids | 8 (16.7) | 6 (16.7) | 2 (16.7) | > 0.999 |
Immunosuppressant | 9 (18.8) | 7 (19.4) | 2 (16.7) | > 0.999 |
Biopharmaceutical | 1 (2.1) | 1 (2.8) | 0 | > 0.999 |
Infective MAC strain; n (%) | ||||
M. avium | 36 (75) | 29 (80.6) | 7 (58.3) | 0.143 |
M. intracellulare | 16 (33.3) | 10 (27.8) | 6 (50) | 0.178 |
With sputum; n (%) | ||||
Positive MAC culture | 32 (66.6) | 25 (69.4) | 7 (58.3) | 0.500 |
With bronchoscopy; n (%) | ||||
Positive culture of MAC | 35/36 (97.2) | 27/28 (96.4) | 6/6 (100) | > 0.999 |
Co-infection at baseline; n(%) | 20 (41.7) | 14(38.9) | 6 (50) | 0.520 |
With sputum | 10 (20.8) | 6 (16.7) | 4 (33.3) | 0.241 |
With bronchoscopy | 14/33 (42.4) | 11/28 (39.3) | 3/6 (50) | 0.672 |
CAM resistant strain; n (%) | ||||
At baseline | 2 (4.2) | 1 (2.8) | 1 (8.3) | 0.441 |
24 months after treatment initiation | 4 (8.3) | 3 (8.3) | 1 (8.3) | > 0.999 |
Treatment for MAC; n (%) | ||||
CAM/EB/RFP | 39 (81.3) | 29 (80.6) | 10 (83.3) | > 0.999 |
CAM/EB | 6 (12.5) | 6 (16.7) | 0 | 0.315 |
Other | 3 (6.3) | 1 (2.8) | 2 (16.7) | 0.156 |
Treatment success; n (%) | 39 (81.2) | 30 (83.3) | 9 (75) | 0.671 |