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Table 5 Univariate analysis of the correlation between baseline lymphocyte subsets and PFS in 125 lung cancer participants

From: Association of lymphocyte subsets with efficacy and prognosis of immune checkpoint inhibitor therapy in advanced non-small cell lung carcinoma: a retrospective study

 

PFS[Month, (95%CI)]

Log rank

P

Gender

 

3.862

0.049

 Male

8.50 (7.02–9.98)

  

 Female

10.00 (6.71–13.29)

  

Age

 

0.877

0.349

 < 65

9.00 (7.44–10.56)

  

 ≥ 65

8.50 (6.78–10.22)

  

Smoker

 

1.481

0.244

 No

9.00 (6.60–11.40)

  

 Yes

8.50 (7.53–9.47

  

Histology

 

1.004

0.316

 Adenocarcinoma

9.50 (8.21–10.80)

  

 Squamous cell carcinoma

7.50 (6.15–8.85)

  

Distant metastasis

 

0.037

0.848

 No

10.00 (7.43–12.58)

  

 Yes

8.50 (7.58–9.42)

  

PD-L1 expression

 

5.034

0.025

 < 50%

7.00 (6.68–10.32)

  

 ≥ 50%

9.00 (7.00–13.01)

  

CD4+ T

 

4.093

0.043

 Low proportion group (< 34.30%)

7.50 (6.41–8.60)

  

 High proportion group (≥  34.30%)

10.00 (8.48–11.52)

  

CD8+ T

 

1.363

0.243

 Low proportion group (< 31.80%)

10.00 (7.59–12.43)

  

 High proportion group (≥ 31.80%)

8.50 (7.08–9.92)

  

CD4+/CD8+

 

4.126

0.042

 Low ratio group (< 1.07)

8.00 (7.00–9.00)

  

 High ratio group (≥ 1.07)

12.00 (9.63–14.37)

  

NK

 

4.212

0.040

 Low proportion group (< 18.90%)

7.50 (6.08–8.92)

  

 High proportion group (≥ 18.90%)

10.00 (8.82–11.18)

  

Tregs

 

2.783

0.095

 Low proportion group (< 6.10%)

7.50 (6.63–8.37)

  

 High proportion group (≥ 6.10%)

10.00 (8.35–11.65)

  

B

 

0.641

0.423

 Low proportion group (< 7.20%)

10.00 (7.97–12.03)

  

 High proportion group (≥ 7.20%)

8.50 (7.33–9.67)

  
  1. Baseline represents the data obtained before immunotherapy