Table 1 Literature review: cases of lepidic predominant adenocarcinoma presenting as bilateral lung, micronodular infiltrates
From: Unusual presentation of lepidic adenocarcinoma in a healthy female
Authors | Sex/age | Associated medical history | Positive diagnostic workup | Diagnostic imaging findings | Treatment |
|---|---|---|---|---|---|
Azzeddine 2020 | F/50 | Personal: type II diabetes mellitus | Micro/Histo: invasive mucinous lepidic adenocarcinoma | CXR/CT: alveolar consolidation of left lower lobe with air bronchogram, multiple nodular lesions and alveolar condensation in right lung | Chemotherapy (names unspecified) |
Daoud 2019 | M/55 | Personal: HTN, smoking (20-years), COPD, cocaine | Micro/Histo: aspergillus, HSV-1, pneumonic type adenocarcinoma | CXR/CT: diffuse bilateral upper/lower lobe opacities with nodular appearance, bilateral parenchymal infiltrates with mediastinal lymphadenopathy | Broad spectrum antibiotics (names not identified), voriconazole, acyclovir |
Pathak 2019 | F/60 | Personal: smoking (20 years) | Micro/Histo: nonmucinous, lepidic predominant adenocarcinoma without invasion, positive TTF-1, EGFR, ALK, and PDL1 1% | CXR/CT: bilateral pulmonary infiltrates and ground glass opacities | Oncology treatment pursued (names unspecified) |
Pathak 2019 | M/55 | Personal: GERD, HLD, smoking (20 years) | Micro/Histo: lepidic predominant adenocarcinoma | CXR/CT: bilateral ground glass opacities, greatest on the left | Oncology treatment pursued (names unspecified) |
Jiménez-Zarazúa et al. (2018) | F/36 | Personal: 33-weeks pregnant, smoking (5 years) Familial: type II diabetes mellitus, hypertension | Micro/Histo: moderately differentiated malignant neoplasia in lepidic pattern | CXR/CT: bilateral opacities, lower-lobe predominant | IV clarithromycin Death prior to cancer treatment |
Mehic 2016 | F/59 | Personal: smoking (22 years), HTN | Micro/Histo: mucinous adenocarcinoma, lepidic predominant, KRAS positive, negative TTF1/napsin/CDX2/7/20 | CXR/CT: reticular interstitial opacities with extended/deformed airways filled with mucous, bronchiectasis, thick interlobular septa | Antibiotics (unspecified), steroids Death prior to cancer treatment |
Takanashi 2016 | F/73 | Personal: Not included in report | Micro/Histo: non-mucinous, lepidic-predominant invasive adenocarcinoma | CXR/CT: extensive ground glass opacities right lower lobe with infiltrative shadow | Pemetrexed Death prior to further treatment |
Nguyen 2014 | F/26 | Personal: uncontrolled type II diabetes mellitus | Micro/Histo: lepidic predominant adenocarcinoma, mucin-secreting neoplastic cells and dense aggregates of mucinous debris in alveoli; positive CAM5.2 immunomarker | CXR/CT: dense perihilar opacities, areas of consolidation, ground glass infiltrates and cystic spaces bilaterally | IV antibiotics (names unspecified) Death prior to cancer treatment |
Thimmareddygari 2021 | M/47 | Personal: Schizophrenia | Micro/Histo: invasive adenocarcinoma; positive for CK7, CK5/6, p63, and Napsin-A | CXR/CT: extensive bilateral airspace opacities, small bilateral pleural effusions, and scattered lucencies in several thoracic vertebrae | Death prior to cancer treatment (planned treatment with osimertinib) |
Ismail 2017 | F/53 | Personal: type II diabetes and hypertension | Micro/Histo: acinar pattern adenocarcinoma positive for transcription termination factor and RNA polymerase 1 | CXR/CT: diffuse bilateral infiltrates, diffuse bilateral confluent nodular and airspace opacities with areas of consolidation in both lung fields with focal mass like consolidation in left upper lobe and several mediastinal lymph nodes | No treatment specified in paper |
Ismail 2017 | F/36 | Personal: no reported past medical history | Micro/Histo: micropapillary adenocarcinoma positive for TTF-1 and cytokeratin. FISH positive for rearrangement involving ROS1 gene | CXR/CT: diffuse bilateral interstitial infiltrates most notable in the upper lungs intermixed with ground glass infiltrates | No treatment specified in paper |
Chang 2004 | N/A/54 | Personal: not included in report | Micro/Histo: adenocarcinoma | CXR/CT: diffuse patchy infiltration and areas of ground glass attenuation | No treatment specified in paper |