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Table 3 Analysis of genotypes of ANO3/MUC15 rs15783, COL4A4 rs1800517, RRBP1 rs11960, and KLK1 rs5516

From: Analysis of the association of ANO3/MUC15, COL4A4, RRBP1, and KLK1 polymorphisms with COPD susceptibility in the Kashi population

Genotype frequency, n (%)

SNV ID

Model

Genotype

Case N (%)

Control N (532)

OR(95%CI)a

pa

OR(95%CI)b

pb

ANO3/MUC15 rs15783

Codominant

A/A

203

196

1

 

1

 
 

A/G

262

237

1.07(0.82–1.39)

0.628

1.01(0.77–1.34)

0.932

 

G/G

76

100

0.74(0.52–1.05)

0.089

0.67(0.46–0.98)

0.038

Dominant

A/A

203

196

1

 

1

 
 

G/G, A/G

338

337

0.97(0.76–1.24)

0.799

0.91(0.70–1.18)

0.476

Recessive

A/A, A/G

465

433

1

 

1

 
 

G/G

76

100

0.71(0.51–0.98)

0.037

0.67(0.47–0.94)

0.021

Additive

–

–

–

0.90(0.75–1.06)

0.202

0.86(0.71–1.02)

0.087

Allele

A

668

629

1

 

1

 
 

G

414

437

0.89(0.75–1.06)

0.196

0.85(0.71–1.02)

0.082

COL4A4 rs1800517

Codominant

A/A

157

137

1

 

1

 
 

A/G

255

258

0.86(0.65–1.15)

0.313

0.81(0.60–1.10)

0.173

 

G/G

128

138

0.81(0.58–1.13)

0.212

0.75(0.53–1.07)

0.114

Dominant

A/A

157

137

1

 

1

 
 

G/G, A/G

383

396

0.84(0.65–1.10)

0.216

0.79(0.60–1.05)

0.104

Recessive

A/A, A/G

412

395

1

 

1

 
 

G/G

128

138

0.89(0.68–1.17)

0.407

0.86(0.64–1.16)

0.319

Additive

–

–

–

0.90(0.76–1.06)

0.208

0.87(0.73–1.03)

0.109

Allele

A

569

532

1

 

1

 
 

G

511

534

0.90(0.76–1.06)

0.198

0.86(0.72–1.03)

0.102

RRBP1 rs11960

Codominant

A/A

170

179

1

 

1

 
 

A/G

267

254

1.11(0.84–1.45)

0.463

1.04(0.79–1.39)

0.789

 

G/G

102

99

1.09(0.77–1.54)

0.646

1.00(0.69–1.44)

0.992

Dominant

A/A

170

179

1

 

1

 
 

G/G, A/G

369

353

1.10(0.85–1.42)

0.462

1.03(0.79–1.35)

0.841

Recessive

A/A, A/G

437

433

1

 

1

 
 

G/G

102

99

1.02(0.75–1.39)

0.895

0.98(0.71–1.35)

0.877

Additive

–

–

–

1.05(0.89–1.25)

0.573

1.00(0.84–1.20)

0.962

Allele

A

607

612

1

 

1

 
 

G

471

452

1.05(0.89–1.25)

0.572

1.00(0.84–1.20)

0.962

KLK1 rs5516

Codominant

G/G

289

269

1

 

1

 
 

G/C

210

202

0.97(0.75–1.25)

0.800

0.98(0.75–1.28)

0.890

 

C/C

38

58

0.61(0.39–0.95)

0.028

0.62(0.39–0.98)

0.042

Dominant

G/G

289

269

1

 

1

 
 

C/C, G/C

248

260

0.89(0.70–1.13)

0.332

0.90(0.70–1.16)

0.417

Recessive

G/G, G/C

499

471

1

 

1

 
 

C/C

38

58

0.62(0.40–0.95)

0.028

0.62(0.40–0.98)

0.039

Additive

–

–

–

0.85(0.71–1.02)

0.087

0.86(0.71–1.04)

0.126

Allele

G

788

740

1

 

1

 
 

C

286

318

0.85(0.70–1.02)

0.079

0.85(0.70–1.04)

0.118

  1. ap values were calculated by logistic regression analysis
  2. bp values were calculated by logistic regression analysis, after adjusting for age, gender, and BMI
  3. The values of p and OR (95%CI), along with the statistical significance, are highlighted in bold
  4. SNV Single nucleotide variation, OR Odds Ratio, 95%CI 95% confidence interval
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BMC Pulmonary Medicine

ISSN: 1471-2466

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