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Table 4 Analysis of genotypes of all SNVs among non-smoker and smoker group

From: Analysis of the association of ANO3/MUC15, COL4A4, RRBP1, and KLK1 polymorphisms with COPD susceptibility in the Kashi population

SNV ID

Model

Genotype

Non-smoking

Smoking

Case

Control

OR(95%CI)

p

Case

Control

OR(95%CI)

p

ANO3/MUC15 rs15783

Codominant

A/A

158

171

1

 

45

25

1

 

A/G

203

206

1.01(0.74–1.37)

0.948

59

31

1.12(0.55–2.26)

0.754

G/G

56

88

0.63(0.42–0.96)

0.032

20

12

0.90(0.36–2.25)

0.817

Dominant

A/A

158

171

1

 

45

25

1

 

G/G, A/G

259

294

0.90(0.67–1.19)

0.450

79

43

1.05(0.55–2.03)

0.878

Recessive

A/A, A/G

361

377

1

 

104

56

1

 

G/G

56

88

0.63(0.43–0.92)

0.017

20

12

0.84(0.37–1.94)

0.689

Additive

–

–

–

0.84(0.68–1.02)

0.075

–

–

0.98(0.62–1.53)

0.914

Allele

A

519

548

1

 

149

81

1

 

G

315

382

0.83(0.68–1.02)

0.071

99

55

0.98(0.62–1.54)

0.913

COL4A4 rs1800517

Codominant

A/A

125

115

1

 

32

22

1

 

A/G

197

226

0.76(0.55–1.06)

0.110

58

32

1.16(0.56–2.46)

0.691

G/G

95

124

0.64(0.44–0.95)

0.026

33

14

1.86(0.76–4.56)

0.174

Dominant

A/A

125

115

1

 

32

22

1

 

G/G, A/G

292

350

0.72(0.53–0.98)

0.039

91

46

1.36(0.68–2.74)

0.388

Recessive

A/A, A/G

322

341

1

 

90

54

1

 

G/G

95

124

0.77(0.55–1.06)

0.108

33

14

1.69(0.79–3.64)

0.178

Additive

–

–

–

0.80(0.66–0.97)

0.025

–

–

1.35(0.87–2.10)

0.182

Allele

A

447

456

1

 

122

76

1

 

G

387

474

0.80(0.65–0.97)

0.023

124

60

1.37(0.87–2.15)

0.169

RRBP1 rs11960

Codominant

A/A

128

165

1

 

42

14

1

 

A/G

212

215

1.21(0.88–1.65)

0.242

55

39

0.41(0.19–0.89)

0.025

G/G

75

84

1.14(0.76–1.72)

0.521

27

15

0.39(0.15–1.01)

0.053

Dominant

A/A

128

165

1

 

42

14

1

 

G/G, A/G

287

299

1.19(0.88–1.60)

0.254

82

54

0.40(0.19–0.85)

0.018

Recessive

A/A, A/G

340

380

1

 

97

53

1

 

G/G

75

84

1.02(0.71–1.47)

0.908

27

15

0.71(0.33–1.53)

0.385

Additive

–

–

–

1.09(0.89–1.33)

0.407

–

–

0.62(0.39–0.98)

0.041

Allele

A

468

545

1

 

139

67

1

 

G

362

383

1.09(0.89–1.33)

0.406

109

69

0.62(0.39–0.98)

0.039

KLK1 rs5516

Codominant

G/G

213

240

1

 

76

29

1

 

G/C

172

170

1.18(0.88–1.59)

0.267

38

32

0.39(0.19–0.77)

0.007

C/C

29

52

0.64(0.38–1.08)

0.096

9

6

0.51(0.16–1.70)

0.276

Dominant

G/G

213

240

1

 

76

29

1

 

C/C, G/C

201

222

1.06(0.80–1.40)

0.697

47

38

0.41(0.21–0.78)

0.007

Recessive

G/G, G/C

385

410

1

 

114

61

1

 

C/C

29

52

0.60(0.36–0.99)

0.046

9

6

0.78(0.25–2.46)

0.671

Additive

–

–

–

0.94(0.76–1.16)

0.557

–

–

0.56(0.34–0.93)

0.024

Allele

G

598

650

1

 

190

90

1

 

C

230

274

0.94(0.75–1.16)

0.549

56

44

0.55(0.33–0.91)

0.020

  1. p values were calculated by logistic regression analysis, after adjusting for age, gender, and BMI
  2. The values of p and OR (95% CI), along with the statistical significance, are highlighted in bold
  3. SNV Single nucleotide variation, OR Odds Ratio, 95%CI 95% confidence interval
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BMC Pulmonary Medicine

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