Analysis of the association of ANO3/MUC15, COL4A4, RRBP1, and KLK1 polymorphisms with COPD susceptibility in the Kashi population

Table 5 Analysis of genotypes of all SNVs at different FEV1 predicted values in COPD patients

SNV ID	Model	Genotype	FEV1 predicted, n		OR(95%CI)	p
SNV ID	Model	Genotype	≥ 50%	< 50%	OR(95%CI)	p
ANO3/MUC15 rs15783	Codominant	A/A	167	36	1
		A/G	210	52	0.88(0.55–1.41)	0.584
		G/G	65	11	1.29(0.62–2.70)	0.497
	Dominant	A/A	167	36	1
	Dominant	G/G, A/G	275	63	0.95(0.60–1.49)	0.819
	Recessive	A/A, A/G	377	88	1
	Recessive	G/G	65	11	1.39(0.71–2.76)	0.340
	Additive	–	–	–	1.06(0.76–1.46)	0.743
	Allele	A	544	124	1
	Allele	G	340	74	1.05(0.77–1.45)	0.746
COL4A4 rs1800517	Codominant	A/A	125	32	1
		A/G	213	42	1.33(0.80–2.22)	0.276
		G/G	103	25	1.08(0.60–1.95)	0.792
	Dominant	A/A	125	32	1
	Dominant	G/G, A/G	316	67	1.24(0.77–1.98)	0.376
	Recessive	A/A, A/G	338	74	1
	Recessive	G/G	103	25	0.91(0.55–1.51)	0.720
	Additive	–	–	–	1.06(0.78–1.43)	0.731
	Allele	A	463	106	1
	Allele	G	419	92	1.06(0.78–1.44)	0.725
RRBP1 rs11960	Codominant	A/A	134	36	1
		A/G	221	46	1.33(0.81–2.17)	0.259
		G/G	85	17	1.40(0.74–2.65)	0.306
	Dominant	A/A	134	36	1
	Dominant	G/G, A/G	306	63	1.346(0.85–2.14)	0.207
	Recessive	A/A, A/G	355	82	1
	Recessive	G/G	85	17	1.18(0.66–2.10)	0.570
	Additive	–	–	–	1.21(0.88–1.66)	0.248
	Allele	A	489	118	1
	Allele	G	391	80	1.20(0.88–1.65)	0.250
KLK1 rs5516	Codominant	G/G	231	58	1
		G/C	176	34	1.30(0.82–2.08)	0.278
		C/C	31	7	1.19(0.49–2.85)	0.702
	Dominant	G/G	231	58	1
	Dominant	C/C, G/C	207	41	1.28(0.82–2.00)	0.279
	Recessive	G/G, G/C	407	92	1
	Recessive	C/C	31	7	1.07(0.45–2.52)	0.877
	Additive	–	–	–	1.18(0.83–1.70)	0.357
	Allele	G	638	150	1
	Allele	C	238	48	1.18(0.83–1.70)	0.356

P values were calculated by logistic regression analysis, after adjusting for age, gender, and BMI
FEV1 Forced expiratory volume in 1 s, SNV Single nucleotide variation, OR Odds Ratio, 95%CI 95% confidence interval

ISSN: 1471-2466