Table 1 Baseline variables of 112 patients considered for lung biopsy from January of 2017 to December of 2019, stratified by MDD recommendation
From: Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
Variable | Total n = 112 | No biopsy n = 31 | TBFB n = 16 | TBCB n = 54 | SLB n = 11 | p value |
|---|---|---|---|---|---|---|
Age, median (p25–p75) | 67 (61–73) | 66 (60–74) | 70 (58–74) | 67 (61–73) | 64 (59–68) | 0.607 |
Male gender, n (%) | 61 (55) | 19 (61) | 6 (38) | 32 (59) | 4 (36) | 0.226 |
Any HP exposure*, n (%) | 33 (30) | 10 (32) | 7 (44) | 13 (24) | 3 (27) | 0.476 |
Positive HP panel, n (%) | 23 (21) | 5 (16) | 7 (44) | 8 (15) | 3 (27) | 0.655 |
CTD symptoms/signs**, n (%) | 13 (12) | 4 (13) | 2 (13) | 5 (9) | 2 (18) | 0.736 |
Any CTD serologies***, n (%) | 20 (18) | 5 (16) | 2 (13) | 11 (20) | 2 (18) | 0.928 |
Pulmonary function tests | ||||||
FVC pp, median (p25–p75) | 71 (57–83) | 69 (57–79) | 69 (54–82) | 73 (57–86) | 71 (58–91) | 0.621 |
DLCO pp, median (p25–p75) | 52 (42–60) | 48 (35–59) | 53 (42–57) | 54 (45–61) | 54 (40–59) | 0.368 |
Radiology pattern, n (%) | < 0.001 | |||||
Definite UIP | 9 (8) | 5 (16) | 1 (6) | 2 (4) | 1 (9) | |
Probable UIP | 44 (39) | 12 (39) | 4 (25) | 27 (50) | 1 (9) | |
Indeterminate for UIP | 12 (11) | 0 (0) | 3 (19) | 9 (17) | 0 (0) | |
NSIP | 17 (15) | 8 (26) | 1 (6) | 5 (9) | 3 (27) | |
HP | 8 (7) | 3 (10) | 3 (19) | 1 (2) | 1 (9) | |
OP | 1 (1) | 0 (0) | 0 (0) | 0 (0) | 1 (9) | |
Smoking-related ILD | 7 (6) | 0 (0) | 2 (13) | 3 (6) | 2 (18) | |
Sarcoidosis | 1 (1) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | |
Unclassifiable | 6 (5) | 0 (0) | 0 (0) | 6 (11) | 0 (0) | |
Other | 7 (6) | 3 (10) | () | 0 (0) | 2 (18) | |
Most likely diagnosis pre-biopsy, n (%) | < 0.001 | |||||
IPF | 22 (20) | 16 (52) | 1 (6) | 5 (9) | 0 (0) | |
NSIP | 7 (6) | 3 (10) | 0 (0) | 3 (6) | 1 (9) | |
CTD-related ILD | 2 (2) | 2 (7) | 0 (0) | 0 (0) | 0 (0) | |
HP | 11 (10) | 4 (13) | 4 (25) | 3 (6) | 0 (0) | |
Indeterminate | 64 (57) | 1 (3) | 11 (69) | 42 (78) | 10 (90) | |
Other | 6 (5) | 5 (16) | 0 (0) | 1 (2) | 0 (0) |