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Table 1 Characteristic of included studies

From: Diagnostic accuracy of interferon-gamma release assays for diagnosis of smear-negative pulmonary tuberculosis: a systematic review and meta-analysis

Author

Year

Country

IGRAs

Study design

Smear negative/ total TB patients

Confirmed TB patients*N (%)

Immunocompromised

History of tuberculosis N (%)

History of BCG vaccination N (%)

Control subjects

HIV N (%)

Non-HIV N (%)

Cattamanchi et al

2010

Uganda

QFT

Prospective

39/126

126 (100)

236 (100)

0 (0)

NA

NA

Other diseases

Lee et al

2010

South Korea

QFT

Retrospective

32/32

32 (100)

NA

NA

18 (21)

NA

Other diseases

Leung et al

2010

Hongkong

QFT

Prospective

188/188

121 (64)

0 (0)

NA

18 (7)

NA

Other diseases

SA Kabeer et al

2010

India

QFT

Case control

26/177

162 (92)

0 (0)

0 (0)

0 (0)

NA

Healthy

Ling et al

2011

South Africa

Both

Prospective

46/138

138 (100)

108 (27)

NA

NA

NA

Other diseases

Lui et al

2011

Hongkong

QFT

Prospective

38/63

60 (95)

2 (1)

16 (9)

44(25)

88(70)

Other diseases

Jung et al

2012

South Korea

Both

Prospective

39/39

60 (95)

0 (0)

119 (100)

24 (20)

29 (30)

Other diseases

Taki-Eddin et al

2012

Syria

QFT

Unclear

13/48

40 (83)

NA

NA

NA

NA

Other diseases

Qian et al

2013

China

QFT

Case control

238/458

NA

NA

NA

NA

NA

Healthy

Park et al

2014

South Korea

QFT

Retrospective

94/94

69 (73)

0 (0)

13(14)

18(19.15)

NA

NA

Qiu et al

2015

China

T-SPOT

Unclear

382/517

224 (59)

0 (0)

NA

NA

NA

Other diseases and healthy

Xia et al

2015

China

QFT

Prospective

171/300

0 (0)

1 (0.3)

0 (0)

0 (0)

NA

Other diseases and healthy

Azghay et al

2016

France

QFT

Retrospective

23/60

39 (65)

5 (8)

5 (8)

NA

NA

Other diseases

Phetsuksiri et al

2018

Thailand

QFT

Case control

49/102

64 (63)

NA

NA

NA

NA

Healthy

Yang et al

2018

China

T-SPOT

Retrospective

2007/2282

640 (28)

0 (0)

86 (4)

NA

NA

Other diseases

Whitworth et al

2019

United Kingdom

Both

Prospective

222/363

261 (72)

135 (16)

17 (2)

NA

649 (77)

Other diseases

  1. BCG, Bacillus Calmette-Guerin; HIV, human immunodeficiency virus; IGRAs, interferon-gamma release assays; QFT, QuantiFERON-TB Gold In-Tube; T-SPOT, T-SPOT.TB; TB, tuberculosis
  2. *Confirmed TB patients defined by active pulmonary tuberculosis patients confirmed diagnosis with isolation of M. tuberculosis or histopathology of caseous granulomatous inflammation