Table 3 Diagnosis accuracy of QuantiFERON-TB Gold In-Tube and T-SPOT.TB

1. QFT-GIT

 1.1 Overall

0.77

(0.71–0.82)

0.70

(0.58–0.80)

2.61

(1.80–3.80)

0.33

(0.25–0.42)

8.03

(4.51–14.31)

 1.2 Risk of bias

  Low risk of bias

0.77

(0.69–0.83)

0.69

(0.56–0.79)

2.46

(1.83–3.31)

0.34

(0.28–0.41)

7.28

(5.39–9.85)

  At risk of bias

0.76

(0.68–0.82)

0.71

(0.50–0.86)

2.64

(1.36–5.12)

0.34

(0.22–0.51)

7.85

(2.81–21.90)

 1.3 TB burden

 High TB burden country

0.74

(0.66–0.81)

0.57

(0.42–0.71)

1.74

(1.30–2.33)

0.45

(0.36–56)

3.84

(2.45–6.02)

 Low TB burden country

0.80

(0.71–0.85)

0.77

(0.62–0.87)

3.39

(2.02–5.68)

0.27

(0.19–0.39)

12.38

(5.92–25.89)

 1.4 Excluding studies of patients with HIV and immunocompromised status

0.79

(0.73–0.84)

0.72

(0.59–0.83)

2.86

(1.86–4.40)

0.29

(0.22–0.38)

8.85

(5.36–18.11)

2.T-SPOT.TB

0.74

(0.71–0.78)

0.71

(0.49–0.86)

2.53

(1.26–5.07)

0.36

(0.24–0.55)

6.96

(2.31–20.98)