Table 2 Acute effects of BaSO4 (4 mg/m3) or sham (0 mg/m3) exposure on blood and induced sputum parameters at different time points [median (minimum–maximum)]
From: No inflammatory effects after acute inhalation of barium sulfate particles in human volunteers
Parameters | Baseline test | BaSO4 [mg/m3] | Directly before exposure | 22 h after exposure | Final examination |
|---|---|---|---|---|---|
Blood | |||||
Leukocytes [1/nL] | 5.50 (4.60–8.50) | 0 | 6.25 (4.80–13.10) | 5.60 (4.30–9.50) | 6.20 (4.50–9.20) |
4 | 5.45 (4.00–8.40) | 6.25 (4.60–13.90) | |||
Neutrophils [%] | 56 (40.8–70) | 0 | 57.5 (38–76) | 60.5 (41–69) | 57 (41–72) |
4 | 55 (41–73) | 56 (48–80) | |||
Neutrophils [1/nL] | 3.08 (2.21–5.94) | 0 | 3.69 (2.00–9.94) | 3.47 (1.76–6.50) | 3.63 (1.87–6.64) |
4 | 3.25 (1.75–6.07) | 3.42 (2.42–11.10) | |||
Lymphocytes [%] | 29 (22–40) | 0 | 30 (14–45) | 29 (19–44) | 32 (19–45) |
4 | 32 (18–47) | 31.5 (11–38) | |||
Lymphocytes [1/nL] | 1.76 (1.37–2.28) | 0 | 1.86 (1.59–2.49) | 1.83 (1.14–2.44) | 1.95 (1.45–2.73) |
4 | 1.69 (1.16–2.79) | 1.81 (0.92–2.82) | |||
Monocytes [%] | 9 (5–12) | 0 | 8.5 (4–12) | 8.5 (5–12) | 8.5 (5–11) |
4 | 7.5 (5–12) | 8 (5–12) | |||
Monocytes [1/nL] | 0.53 (0.34–0.81) | 0 | 0.53 (0.39–0.82) | 0.55 (0.3–0.72) | 0.47 (0.33–0.82) |
4 | 0.47 (0.30–0.65) | 0.50 (0.31–1.00) | |||
Thrombocytes [1/nL] | 242 (192–346) | 0 | 253 (181–339) | 238 (168–339) | 231 (176–339) |
4 | 226 (172–344) | 231 (178–326) | |||
Erythrocytes [1/nL] | 4.75 (4.10–5.35) | 0 | 4.80 (4.10–5.50) | 4.75 (4.10–5.40) | 4.80 (4.00–5.30) |
4 | 4.75 (4.10–5.60) | 4.85 (3.90–5.50) | |||
CRP [mg/L] | 0.78 (0.06–4.24) | 0 | 0.92 (0.08–3.63) | 1.05 (0.04–4.73) | 0.89 (0.00–7.12) |
4 | 0.86 (0.06–7.33) | 1.14 (0.00–5.43) | |||
SAA [µg/L] | 10,873 (< 1880–51,897) | 0 | 15,366 (3262–87,932) | 18,379 (3607–256,193) | 11,082 (< 1880–158,188) |
4 | 8674 (2381–46,633) | 10,318 (< 1880–107,439) | |||
Induced sputum | |||||
IL-8 [ng/L] | 1771 (193–12,768) | 0 | – | 684 (164–16,177) | 1303 (219–12,775) |
4 | – | 1128 (166–36,918) | |||
MMP-9 [µg/L] | 161 (33–852) | 0 | – | 61 (15–764) | 58 (13–335) |
4 | – | 104 (20–1329) | |||
TIMP-1 [µg/L] | 9.27 (0.82–41.40) | 0 | – | 3.26 (1.01–30.12) | 2.65 (0.57–21.65) |
4 | – | 4.62 (0.91–54.50) | |||
Total protein [mg/L] | 260 (76–846) | 0 | – | 189 (66–698) | 146 (67–477) |
4 | – | 197 (59–931) | |||
Total cell number [× 105] | 60.33 (5.00–108.41) | 0 | – | 29.63 (8.55–212.44) | 28.60 (7.33–62.73) |
4 | – | 35.10 (8.86–140.10) | |||
Neutrophils [%] | 8.75 (0–34) | 0 | – | 1.5 (0–40) | 3 (0–28) |
4 | – | 1.25 (0–32.5) | |||
Neutrophils [× 104] | 37.85 (0–368.61) | 0 | – | 5.13 (0–484.59) | 8.2 (0–133) |
4 | – | 5.62 (0–455.33) | |||