Table 1 Clinical characteristics of the 30 CF children
Characteristics | With bronchial congestion N = 10 | Without bronchial congestion N = 20 | Between 2 groups (with and without) at baseline |
|---|---|---|---|
Ethnicity C/B/A/M | 9/0/1/0 | 16/2/0/2 | 0.253 |
Age, years | 14.6 [9.7; 16.3] | 11.8 [7.9; 14.5] | 0.333 |
Sex, female/male | 7/3 | 5/15 | 0.045 |
Weight, kg | 40.5 [33.8; 48.0] | 40.0 [23.0; 50.5] | 0.552 |
Weight z-score | − 0.60 [− 0.84; − 0.03] | − 0.66 [− 1.13; 0.04] | 0.391 |
Height, cm | 150 [139; 160] | 146 [122; 160] | 0.843 |
Height z-score | − 0.44 [− 1.03; 0.16] | − 0.75 [− 1.04; 0.00] | 0.644 |
BMI z-score | − 0.48 [− 0.58; − 0.03] | − 0.34 [− 0.89; 0.71] | 0.509 |
Pancreatic insufficiency, n | 10 | 17 | 0.519 |
Previous pseudomonas aeruginosa colonisation, n | 10 | 13 | 0.093 |
Dornase alfa/azithromycin, n | 9/3 | 17/5 | ND |
Inhaled β-agonist/corticosteroid, n | 1/1 | 3/3 | ND |
CFTR modulator therapy, n | 4 | 5 | ND |
Mutation | |||
Homozygous /heterozygous/other* | 4/4/2 | 7/6/7 | 0.689 |
Score (VAS) of congestion | 6.5 [5.0; 7.0] | 2.0 [1.0; 3.0] | ND |
Sputum weight, g | 7.9 [6.1; 12.1] | 1.7 [0.9; 4.5] | < 0.001 |
Congestion absent/present# | 1/9 | 13/7 | 0.007 |