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Table 5 Univariate and multivariate analyses of prognostic factors for patients with PAH without pulmonary vasodilator treatment

From: Mixed venous oxygen tension is a crucial prognostic factor in pulmonary hypertension: a retrospective cohort study

Variable

Univariate

Multivariate model 1

Multivariate model 2

HR (95% CIv)

P

HR (95% CIv)

P

HR (95% CIv)

P

Age (years)

1.02 (0.993–1.044)

0.155

1.02 (0.987–1.045)

0.279

1.02 (0.987–1.046)

0.272

RAP (mmHg)

1.06 (0.924–1.220)

0.416

0.95 (0.797–1.195)

0.533

  

mPAP (mmHg)

1.03 (1.001–1.050)

0.041

    

CI (L/min/m2)

0.31 (0.170–0.531)

 < 0.001

0.56 (0.255–1.144)

0.112

  

PVR (W.U)

1.12 (1.066–1.187)

 < 0.001

    

PaO2 (mmHg)

0.98 (0.946–1.010)

0.170

    

PvO2 (mmHg)

0.77 (0.690–0.854)

 < 0.001

0.82 (0.700–0.937)

0.003

  

PvO2 < 35 mmHg

11.94 (4.007–35.554)

 < 0.001

  

6.45 (1.626–25.568)

0.003

RAP ≥ 8 mmHg

0.98 (0.333–2.891)

0.972

  

0.84 (0.263–2.658)

0.759

CI < 2.5 L/min/m2

6.18 (2.551–14.950)

 < 0.001

  

2.57 (0.771–8.548)

0.135

SvO2 (mmHg)

0.86 (0.812–0.916)

 < 0.001

    

A-aDO2 (mmHg)

1.05 (1.012–1.085)

0.009

    

BNP (pg/mL)

1.00 (0.992–1.007)

0.903

    

6MWD (m)

0.99 (0.952–1.009)

0.105

    

FVC, %pred. (%)

0.99 (0.965–1.026)

0.719

    

DLCO, %pred. (%)

0.96 (0.917–0.991)

0.011

    

WHO functional class I + II (vs. III + IV)

0.16 (0.047–0.572)

 < 0.001

    
  1. Statistically significant, P < 0.05, are shown in bold
  2. A-aDO2 alveolar-arterial oxygen gradient, BNP brain natriuretic peptide, CI cardiac index, CIv confidence interval, DLCO, %pred. percent predicted carbon monoxide diffusing capacity, FVC, %pred. percent predicted forced vital capacity, HR hazard ratio, mPAP mean pulmonary arterial pressure, PAH pulmonary arterial hypertension, PaO2 arterial oxygen tension, PvO2 mixed venous oxygen tension, PVR pulmonary vascular resistance, RAP right arterial pressure, SvO2 mixed venous oxygen saturation, WHO World Health Organization, W.U Wood units, 6MWD 6-min walk distance
  3. Model 1: Multivariate analysis by ESC/ERS risk stratification and age
  4. Model 2: Multivariate analysis by ESC/ERS and French risk stratification in yellow and red zone, and age