Mixed venous oxygen tension is a crucial prognostic factor in pulmonary hypertension: a retrospective cohort study

Table 7 Univariate and multivariate analyses of prognostic factors for patients in the CTEPH PEA/BPA group

Variable	Univariate		Multivariate model 1		Multivariate model 2		Multivariate model 3
Variable	HR (95% CIv)	P	HR (95% CIv)	P	HR (95% CIv)	P	HR (95% CIv)	P
Age (years)	1.04 (0.991–1.085)	0.120	1.05 (1.001–1.097)	0.044	1.04 (0.991–1.087)	0.120	1.06 (0.999–1.139)	0.053
RAP (mmHg)	1.05 (0.929–1.158)	0.432	1.10 (0.967–1.261)	0.209
mPAP (mmHg)	1.03 (0.987–1.083)	0.153
CI (L/min/m²)	0.75 (0.334–1.560)	0.455	0.70 (0.272–1.587)	0.413
PVR (W.U)	1.08 (0.958–1.198)	0.209
PaO₂ (mmHg)	1.00 (0.954–1.054)	0.873
PvO₂ (mmHg)	1.05 (0.928–1.197)	0.419	1.15 (0.989–1.352)	0.069			1.02 (0.831–1.267)	0.851
PvO₂ < 35 mmHg	1.54 (0.507–4.659)	0.430			1.22 (0.368–4.039)	0.742
RAP ≥ 8 mmHg	1.38 (0.447–4.229)	0.589			1.51 (0.438–5.215)	0.523
CI < 2.5 L/min/m²	1.26 (0.515–3.064)	0.616			1.07 (0.389–2.923)	0.901
SvO₂ (mmHg)	0.99 (0.925–1.058)	0.730
A-aDO₂ (mmHg)	0.97 (0.932–1.018)	0.241
BNP (pg/mL)	1.00 (0.998–1.002)	0.603
6MWD (m)	0.99 (0.988–0.999)	0.030					0.99 (0.988–1.001)	0.098
FVC, %pred. (%)	0.96 (0.957–1.006)	0.123
DLCO, %pred. (%)	0.98 (0.952–0.998)	0.033					0.98 (0.951–1.014)	0.279
WHO functional class I + II (vs. III + IV)	0.31 (0.070–1.332)	0.067

Statistically significant, P < 0.05, are shown in bold
A-aDO₂ alveolar-arterial oxygen gradient, BNP brain natriuretic peptide, BPA balloon pulmonary angioplasty, CI cardiac index, CIv confidence interval, CTEPH chronic thromboembolic pulmonary hypertension, DLCO, %pred. percent predicted carbon monoxide diffusing capacity, FVC, %pred. percent predicted forced vital capacity, HR hazard ratio, mPAP mean pulmonary arterial pressure, PaO₂ arterial oxygen tension, PEA pulmonary endarterectomy, PvO₂ mixed venous oxygen tension, PVR pulmonary vascular resistance, RAP right arterial pressure, SvO₂ mixed venous oxygen saturation, WHO World Health Organization, W.U Wood units, 6MWD 6-min walk distance
Model 1: Multivariate analysis by ESC/ERS risk stratification and age
Model 2: Multivariate analysis by ESC/ERS and French risk stratification in yellow and red zone, and age
Model 3: Multivariate analysis adding age and PvO₂ to variables that were significant in univariate analysis

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