Mixed venous oxygen tension is a crucial prognostic factor in pulmonary hypertension: a retrospective cohort study

Table 8 Univariate and multivariate analyses of prognostic factors for patients in the CTEPH PH medication group

Variable	Univariate		Multivariate model 1		Multivariate model 2		Multivariate model 3
Variable	HR (95% CIv)	P	HR (95% CIv)	P	HR (95% CIv)	P	HR (95% CIv)	P
Age (years)	0.99 (0.959–1.020)	0.427	0.99 (0.951–1.025)	0.479	0.99 (0.966–1.027)	0.701	0.99 (0.955–1.033)	0.730
RAP (mmHg)	1.13 (1.034–1.237)	0.008	1.00 (0.864–1.127)	0.958			0.99 (0.861–1.119)	0.889
mPAP (mmHg)	1.05 (1.013–1.085)	0.008					0.99 (0.923–1.054)	0.688
CI (L/min/m²)	0.59 (0.352–1.034)	0.064	1.26 (0.569–2.983)	0.575
PVR (W.U)	1.17 (1.081–1.264)	< 0.001					1.06 (0.895–1.250)	0.499
PaO₂ (mmHg)	0.95 (0.904–0.994)	0.025
PvO₂ (mmHg)	0.74 (0.651–0.842)	< 0.001	0.73 (0.625–1.367)	< 0.001			0.77 (0.633–0.930)	0.006
PvO₂ < 35 mmHg	4.83 (1.133–20.608)	0.008			4.26 (0.871–20.820)	0.047
RAP ≥ 8 mmHg	2.80 (1.226–6.418)	0.019			2.08 (0.786–5.490)	0.142
CI < 2.5 L/min/m²	2.11 (0.931–4.782)	0.067			0.88 (0.317–2.416)	0.798
SvO₂ (mmHg)	0.87 (0.816–0.924)	< 0.001
A-aDO₂ (mmHg)	1.07 (1.025–1.111)	0.002
BNP (pg/mL)	1.00 (1.001–1.004)	0.002
6MWD (m)	0.99 (0.984–0.994)	< 0.001
FVC, %pred. (%)	0.99 (0.971–1.004)	0.112
DLCO, %pred. (%)	0.99 (0.977–1.011)	0.492
WHO functional class I + II (vs. III + IV)	0.22 (0.053–0.968)	0.014

Statistically significant, P < 0.05, are shown in bold
A-aDO₂ alveolar-arterial oxygen gradient, BNP brain natriuretic peptide, CI cardiac index, CIv confidence interval, CTEPH chronic thromboembolic pulmonary hypertension, DLCO, %pred. percent predicted carbon monoxide diffusing capacity, FVC, %pred. percent predicted forced vital capacity, HR hazard ratio, mPAP mean pulmonary arterial pressure, PaO₂ arterial oxygen tension, PH pulmonary hypertension, PvO₂ mixed venous oxygen tension, PVR pulmonary vascular resistance, RAP right arterial pressure, SvO₂ mixed venous oxygen saturation, WHO World Health Organization, W.U Wood units, 6MWD 6-min walk distance
Model 1: Multivariate analysis by ESC/ERS risk stratification and age
Model 2: Multivariate analysis by ESC/ERS and French risk stratification in yellow and red zone, and age
Model 3: Multivariate analysis adding age and PvO₂ to variables that were significant in univariate analysis

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