Fig. 2

Correlation between the levels of peripheral blood CD8⁺CD28⁻ and CD4⁺CD25^highTreg cells and the disease course of patients with TB. A Statistical analysis of the frequencies of CD8⁺CD28⁻Treg cells among the CD8⁺ population was compared among the HC, PTB-Stage I and PTB-Stage II groups. B Statistical analysis of the frequencies of CD4⁺CD25^highTreg cells among the CD4⁺ population was compared among the HC, PTB-Stage I and PTB-Stage II groups. C Statistical analysis of the frequencies of CD8⁺CD28⁻ Treg cells among the CD8⁺ population was compared among the subgroups of PTB patients with different bacillary loads in their sputum. D Statistical analysis of the frequencies of CD4⁺CD25^highTreg cells among the CD4⁺ population was compared among the subgroups of PTB patients with different bacillary loads in their sputum. + : 3–9 strips/100 visual fields, +  + : 1–9 strips/10 visual fields, +  +  + : 1–9/field and +  +  +  + : ≥ 10 strips/field