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Table 1 Clinical characteristics of patients with stage I NSCLC before PSM

From: Impact of preoperative biopsy on tumor spread through air spaces in stage I non-small cell lung cancer: a propensity score-matched study

Variable

PNB (n = 40)

BB (n = 48)

Non-biopsy (n = 345)

P-value*

P-value#

Gender

 Female

20(50.0)

10(20.8)

170(49.3)

0.931

 < 0.001

 Male

20(50.0)

38(79.2)

175(50.7)

  

Age

62.88 ± 8.890

63.52 ± 8.119

62.14 ± 8.052

0.589

0.267

Smoking history

 No

27(67.5)

14(29.2)

204(59.1)

0.306

 < 0.001

 Yes

13(32.5)

34(70.8)

141(40.9)

  

Tumor location

 Peripheral

37(92.5)

9(18.8)

319(92.5)

1.000$

 < 0.001

 Central

3(7.5)

39(81.3)

26(7.5)

  

Scope of surgery

 Lobectomy

39(97.5)

47(97.9)

333(96.5)

1.000$

1.000$

 Sublobar resection

1(2.5)

1(2.1)

12(3.5)

  

Pathological type

 Adenocarcinoma

33(82.5)

8(16.7)

295(85.5)

0.173$

 < 0.001$

 Squamous carcinoma

5(12.5)

37(77.1)

46(13.3)

  

 Other

2(5.0)

3(6.3)

4(1.2)

  

Staging

 Stage Ia

18(57.1)

30(62.5)

197(57.1)

0.145

0.478

 Stage Ib

22(42.9)

18(37.5)

148(42.9)

  

Maximum tumor diameter

2.26 ± 0.90

2.34 ± 1.18

2.16 ± 0.80

0.434

0.160

Postoperative adjuvant therapy

 No

20(50.0)

30(62.5)

254(73.6)

0.002

0.107

 Yes

20(50.0)

18(37.5)

91(26.4)

  

STAS

 No

24(60.0)

27(56.2)

206(59.7)

0.972

0.648

 Yes

16(40.0)

21(43.8)

139(40.3)

  

STAS degree

 None

24(60.0)

27(56.2)

206(59.7)

0.191$

0.324$

 Limited

0(0.0)

1(2.1)

24(7.0)

  

 Extensive

16(40.0)

20(41.7)

115(33.3)

  
  1. NSCLC non-small cell lung cancer, PSM propensity score matching, PNB percutaneous needle biopsy, BB bronchoscopic biopsy, STAS tumor spread through air spaces
  2. *P-value: PNB group versus non-biopsy group
  3. #P-value 2: BB group versus non-biopsy group
  4. $Using Fisher’s exact test