Clinical features and treatment outcome of lymphoepithelioma-like carcinoma from multiple primary sites: a population-based, multicentre, real-world study

Table 2 Univariate and multivariate analyses of potential prognostic factors for OS

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	HR (95% CI)	P value	HR (95% CI)	P value
Age
< 60
≥ 60	1.141(0.736–1.768)	0.555	0.969(0.617–1.525)	0.894
Gender
Male
Female	1.025(0.976–1.482)	0.896	1.015(0.655–1.572)	0.947
ECOG score
< 2
≥ 2	3.828(2.331–6.287)	< 0.0001***	1.753(1.031–2.980)	0.038*
Stages
I–II
III–IV	9.152(4.257–19.67)	< 0.0001***	5.560(2.510–12.34)	< 0.0001***
Lung origin	2.144(1.225–3.753)	0.0076**	1.581(0.862–2.899)	0.138
Lung metastasis	3.062(1.885–4.973)	< 0.0001***	0.852(0.490–1.480)	0.569
Bone metastasis	4.761(3.178–7.132)	< 0.0001***	1.793(1.107–2.903)	0.0176*
Liver metastasis	7.145(4.715–10.83)	< 0.0001***	2.591(1.537–4.369)	0.0003***
Pleura metastasis	3.639(2.409–5.495)	< 0.0001***	0.948(0.569–1.580)	0.838
Non-regional lymph node metastasis	4.789(3.124–7.341)	< 0.0001***	1.642(0.968–2.783)	0.065
Adrenal metastasis	3.989 (1.625–9.79)	0.0025**	0.774(0.292–2.054)	0.607
Smoker	1.087(0.688–1.718)	0.72	0.936(0.541–1.619)	0.814
High EBV DNA copy	3.750(2.585–5.441)	< 0.0001***	1.726(1.134–2.626)	0.011*

HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group, EBV Epstein-Barr virus

ISSN: 1471-2466