Table 3 Measures of diagnostic accuracy for TuM2-PK and CEA assays in pleural effusion and serum in MPE
Marker | Cut-off | AUC (95% Cl) | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|---|---|
TuM2-PK | ||||||||
Pleural effusion | 28.67 u/ml | 0.856 (0.781–0.932) | 68.8 | 52.5 | 62.4 | 69.4 | 51.9 | |
Serum | 15.83 u/ml | 0.816 (0.729–0.903) | 60.8 | 58.8 | 60.0 | 69.7 | 49.0 | |
CEA | ||||||||
Pleural effusion | 8.76 ng/ml | 0.732 (0.631–0.832) | 61.6 | 71.3 | 65.4 | 77.0 | 54.3 | |
Serum | 5.53 ng/ml | 0.665 (0.556–0.774) | 51.2 | 63.8 | 56.1 | 68.8 | 45.5 | |
TuM2-PK + CEA | ||||||||
Pleural effusion | 0.922 (0.867–0.977) | 91.2 | 83.8 | 88.3 | 89.8 | 85.9 | ||
Serum | 0.863 (0.788–0.938) | 80.8 | 71.3 | 77.1 | 81.5 | 70.4 | ||